Bioactive Proteins in Human Milk: Mechanisms of Action

Bo Lönnerdal

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Human milk contains a multitude of bioactive proteins, with very diverse functions. Some of these proteins are involved in the synthesis and expression of milk, but the majority appears to have evolved to provide physiological activities in the breast-fed infant. These activities are exerted by a wide variety of mechanisms and have largely been unraveled by in vitro studies. To be active in the gastrointestinal tract, these proteins must be able to resist proteolytic degradation, at least for some time. We have evaluated the human milk proteins lactoferrin, haptocorrin, α1-antitrypsin, and transforming growth factor -β in an in vitro digestion model, mimicking the conditions of the infant gastrointestinal milieu. These bioactive proteins are resistant against proteolysis and can remain intact or as larger fragments through passage of the gastrointestinal tract. In vitro digestibility assays can be helpful to assess which human milk proteins can resist proteolysis and to what extent.

Original languageEnglish (US)
JournalJournal of Pediatrics
Volume156
Issue number2 SUPPL.
DOIs
StatePublished - Feb 2010

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Human Milk
Milk Proteins
Proteolysis
Gastrointestinal Tract
Proteins
Transcobalamins
Lactoferrin
Transforming Growth Factors
Digestion
Milk
Breast
In Vitro Techniques

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Bioactive Proteins in Human Milk : Mechanisms of Action. / Lönnerdal, Bo.

In: Journal of Pediatrics, Vol. 156, No. 2 SUPPL., 02.2010.

Research output: Contribution to journalArticle

Lönnerdal, Bo. / Bioactive Proteins in Human Milk : Mechanisms of Action. In: Journal of Pediatrics. 2010 ; Vol. 156, No. 2 SUPPL.
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