Binge Drinking Prior to Pregnancy Detection in a Nonhuman Primate

Behavioral Evaluation of Offspring

Mari S. Golub, Casey E. Hogrefe, Catherine A. Vandevoort

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Minimal scientific information is available to inform public health policy on binge drinking prior to pregnancy detection. The nonhuman primate provides a valuable animal model for examining consequences to reproduction and offspring function that may result from this common pattern of alcohol abuse. Methods: Adult female rhesus monkeys were dosed with 1.5 g/kg per day ethanol (EtOH) by gavage 2 d/wk beginning 7 months prior to mating and continuing to pregnancy detection at 19 to 20 days gestation. Postnatal evaluation of control (n = 6) and EtOH-treated (n = 4) infants included a neonatal neurobehavioral assessment, a visual paired comparison (cognitive) test at 35 days of age, and mother-infant interaction at 100 to 112 days of age. Results: Alcohol-exposed neonates did not differ from controls in posture and reflex measures. Longer durations of visual fixation, suggesting slower visual processing, and greater novelty preference were seen in the alcohol group. At early weaning age, as infants spent more time away from their dams, more of the reunions between mother and infant were initiated by the mothers in the alcohol-exposed group, suggesting a more immature mother-infant interaction. Conclusions: Intermittent high-dose alcohol exposure (binge drinking) discontinued at early pregnancy detection in rhesus monkey can result in altered behavioral function in the infant. Mediating effects on ovum, reproductive tract, and early embryo can be explored in this model. Studies of longer-term consequences in human populations and animal models are needed.

Original languageEnglish (US)
Pages (from-to)551-556
Number of pages6
JournalAlcoholism: Clinical and Experimental Research
Volume38
Issue number2
DOIs
StatePublished - Feb 2014

Fingerprint

Binge Drinking
Primates
Alcohols
Mother-Child Relations
Pregnancy
Macaca mulatta
Animal Models
Reunion
Mothers
Animals
Matched-Pair Analysis
Public Policy
Health Policy
Weaning
Posture
Alcoholism
Reproduction
Ovum
Reflex
Public health

Keywords

  • Binge Drinking
  • Mother-Infant Interaction
  • Pregnancy
  • Rhesus Monkey
  • Visual Information Processing

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Toxicology

Cite this

Binge Drinking Prior to Pregnancy Detection in a Nonhuman Primate : Behavioral Evaluation of Offspring. / Golub, Mari S.; Hogrefe, Casey E.; Vandevoort, Catherine A.

In: Alcoholism: Clinical and Experimental Research, Vol. 38, No. 2, 02.2014, p. 551-556.

Research output: Contribution to journalArticle

Golub, Mari S. ; Hogrefe, Casey E. ; Vandevoort, Catherine A. / Binge Drinking Prior to Pregnancy Detection in a Nonhuman Primate : Behavioral Evaluation of Offspring. In: Alcoholism: Clinical and Experimental Research. 2014 ; Vol. 38, No. 2. pp. 551-556.
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