Bilaterally symmetric focal cortical dysplasia in a golden retriever dog

K. M. Casey, A. W. Bollen, K. M. Winger, Karen Vernau, Peter J Dickinson, Robert Higgins, S. Sisó

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A 10-year-old golden retriever dog was referred with a 24-h history of generalized seizures. Magnetic resonance imaging of the brain found no abnormalities on 3mm transverse sections and the dog was subsequently humanely destroyed. Microscopically there was bilaterally symmetrical focal disorganization of cortical grey matter within the tips of the right and left suprasylvian gyri of the temporal cortex. The focal abnormal cortical lamination was characterized by loss of pyramidal neurons with abnormal, irregular, angular, remaining neurons occasionally forming clusters, surrounded by fibrillary astrogliosis and microgliosis and vascular proliferation. These histological findings are consistent with focal cortical dysplasia, a cerebral cortical malformation that causes seizures in people, but not reported previously in the dog.

Original languageEnglish (US)
Pages (from-to)375-379
Number of pages5
JournalJournal of Comparative Pathology
Volume151
Issue number4
DOIs
StatePublished - 2014

Fingerprint

Malformations of Cortical Development
Golden Retriever
Dogs
seizures
dogs
Seizures
neurons
Pyramidal Cells
Temporal Lobe
magnetic resonance imaging
blood vessels
Blood Vessels
cortex
Magnetic Resonance Imaging
brain
Neurons
Brain

Keywords

  • Dog
  • Focal cortical dysplasia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • veterinary(all)

Cite this

Bilaterally symmetric focal cortical dysplasia in a golden retriever dog. / Casey, K. M.; Bollen, A. W.; Winger, K. M.; Vernau, Karen; Dickinson, Peter J; Higgins, Robert; Sisó, S.

In: Journal of Comparative Pathology, Vol. 151, No. 4, 2014, p. 375-379.

Research output: Contribution to journalArticle

Casey, K. M. ; Bollen, A. W. ; Winger, K. M. ; Vernau, Karen ; Dickinson, Peter J ; Higgins, Robert ; Sisó, S. / Bilaterally symmetric focal cortical dysplasia in a golden retriever dog. In: Journal of Comparative Pathology. 2014 ; Vol. 151, No. 4. pp. 375-379.
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