Abstract
A 10-year-old golden retriever dog was referred with a 24-h history of generalized seizures. Magnetic resonance imaging of the brain found no abnormalities on 3mm transverse sections and the dog was subsequently humanely destroyed. Microscopically there was bilaterally symmetrical focal disorganization of cortical grey matter within the tips of the right and left suprasylvian gyri of the temporal cortex. The focal abnormal cortical lamination was characterized by loss of pyramidal neurons with abnormal, irregular, angular, remaining neurons occasionally forming clusters, surrounded by fibrillary astrogliosis and microgliosis and vascular proliferation. These histological findings are consistent with focal cortical dysplasia, a cerebral cortical malformation that causes seizures in people, but not reported previously in the dog.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 375-379 |
| Number of pages | 5 |
| Journal | Journal of Comparative Pathology |
| Volume | 151 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2014 |
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Keywords
- Dog
- Focal cortical dysplasia
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- veterinary(all)
Cite this
Bilaterally symmetric focal cortical dysplasia in a golden retriever dog. / Casey, K. M.; Bollen, A. W.; Winger, K. M.; Vernau, Karen; Dickinson, Peter J; Higgins, Robert; Sisó, S.
In: Journal of Comparative Pathology, Vol. 151, No. 4, 2014, p. 375-379.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bilaterally symmetric focal cortical dysplasia in a golden retriever dog
AU - Casey, K. M.
AU - Bollen, A. W.
AU - Winger, K. M.
AU - Vernau, Karen
AU - Dickinson, Peter J
AU - Higgins, Robert
AU - Sisó, S.
PY - 2014
Y1 - 2014
N2 - A 10-year-old golden retriever dog was referred with a 24-h history of generalized seizures. Magnetic resonance imaging of the brain found no abnormalities on 3mm transverse sections and the dog was subsequently humanely destroyed. Microscopically there was bilaterally symmetrical focal disorganization of cortical grey matter within the tips of the right and left suprasylvian gyri of the temporal cortex. The focal abnormal cortical lamination was characterized by loss of pyramidal neurons with abnormal, irregular, angular, remaining neurons occasionally forming clusters, surrounded by fibrillary astrogliosis and microgliosis and vascular proliferation. These histological findings are consistent with focal cortical dysplasia, a cerebral cortical malformation that causes seizures in people, but not reported previously in the dog.
AB - A 10-year-old golden retriever dog was referred with a 24-h history of generalized seizures. Magnetic resonance imaging of the brain found no abnormalities on 3mm transverse sections and the dog was subsequently humanely destroyed. Microscopically there was bilaterally symmetrical focal disorganization of cortical grey matter within the tips of the right and left suprasylvian gyri of the temporal cortex. The focal abnormal cortical lamination was characterized by loss of pyramidal neurons with abnormal, irregular, angular, remaining neurons occasionally forming clusters, surrounded by fibrillary astrogliosis and microgliosis and vascular proliferation. These histological findings are consistent with focal cortical dysplasia, a cerebral cortical malformation that causes seizures in people, but not reported previously in the dog.
KW - Dog
KW - Focal cortical dysplasia
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UR - http://www.scopus.com/inward/citedby.url?scp=84923302943&partnerID=8YFLogxK
U2 - 10.1016/j.jcpa.2014.08.002
DO - 10.1016/j.jcpa.2014.08.002
M3 - Article
C2 - 25246180
AN - SCOPUS:84923302943
VL - 151
SP - 375
EP - 379
JO - Journal of Comparative Pathology
JF - Journal of Comparative Pathology
SN - 0021-9975
IS - 4
ER -