Bilateral [14C]2-deoxyglucose uptake by motor pathways after unilateral neonatal cortex lesions in the rat

Frank R Sharp, Kathleen L. Evans

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The left sensorimotor (SM) cortex was removed in 1-day-old and 30-day-old rats. At 90 days of age [14C]2-deoxyglucose (2DG) was injected and the right motor (MI) cortex was electrically stimulated to produce predominantly left vibrissae movements. Animals were sacrificed and their brains autoradiographed. Right motor cortex (MI) stimulation activated subcortical structures bilaterally in 3 of 5 neonatally lesioned rats. Right MI stimulation activated most subcortical structures unilaterally in 30-day lesioned rats. This implies that a critical period for SM cortex injury may occur between 1 and 30 days of age. We suggest that removal of left SM cortex at 1 day of age occurs before or during the critical period and this induces right MI cortex to form bilateral subcortical connections. The bilateral 2DG uptake increases imply the bilateral connections are functional. The unilateral subcortical activation in 2 of 5 neonatally lesioned animals may have been due to differences in size of the lesion, parameters of stimulation, or perhaps due to the time of the lesion being near the critical period. We also suggest that removal of left SM cortex at 30 days of age occurs after the critical period, but that this does not affect the predominantly ipsilateral subcortical connections from MI cortex which have previously formed during normal development.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalDevelopmental Brain Research
Volume6
Issue number1
DOIs
StatePublished - 1982

Fingerprint

Efferent Pathways
Deoxyglucose
Motor Cortex
Vibrissae
Sensorimotor Cortex
Wounds and Injuries
Brain

Keywords

  • 2-deoxyglucose
  • motor cortex
  • neonatal lesions
  • plasticity

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Bilateral [14C]2-deoxyglucose uptake by motor pathways after unilateral neonatal cortex lesions in the rat. / Sharp, Frank R; Evans, Kathleen L.

In: Developmental Brain Research, Vol. 6, No. 1, 1982, p. 1-11.

Research output: Contribution to journalArticle

@article{b5c2dd841bd74beabd945c0bc3b8e131,
title = "Bilateral [14C]2-deoxyglucose uptake by motor pathways after unilateral neonatal cortex lesions in the rat",
abstract = "The left sensorimotor (SM) cortex was removed in 1-day-old and 30-day-old rats. At 90 days of age [14C]2-deoxyglucose (2DG) was injected and the right motor (MI) cortex was electrically stimulated to produce predominantly left vibrissae movements. Animals were sacrificed and their brains autoradiographed. Right motor cortex (MI) stimulation activated subcortical structures bilaterally in 3 of 5 neonatally lesioned rats. Right MI stimulation activated most subcortical structures unilaterally in 30-day lesioned rats. This implies that a critical period for SM cortex injury may occur between 1 and 30 days of age. We suggest that removal of left SM cortex at 1 day of age occurs before or during the critical period and this induces right MI cortex to form bilateral subcortical connections. The bilateral 2DG uptake increases imply the bilateral connections are functional. The unilateral subcortical activation in 2 of 5 neonatally lesioned animals may have been due to differences in size of the lesion, parameters of stimulation, or perhaps due to the time of the lesion being near the critical period. We also suggest that removal of left SM cortex at 30 days of age occurs after the critical period, but that this does not affect the predominantly ipsilateral subcortical connections from MI cortex which have previously formed during normal development.",
keywords = "2-deoxyglucose, motor cortex, neonatal lesions, plasticity",
author = "Sharp, {Frank R} and Evans, {Kathleen L.}",
year = "1982",
doi = "10.1016/0165-3806(82)90168-7",
language = "English (US)",
volume = "6",
pages = "1--11",
journal = "Developmental Brain Research",
issn = "0165-3806",
publisher = "Elsevier BV",
number = "1",

}

TY - JOUR

T1 - Bilateral [14C]2-deoxyglucose uptake by motor pathways after unilateral neonatal cortex lesions in the rat

AU - Sharp, Frank R

AU - Evans, Kathleen L.

PY - 1982

Y1 - 1982

N2 - The left sensorimotor (SM) cortex was removed in 1-day-old and 30-day-old rats. At 90 days of age [14C]2-deoxyglucose (2DG) was injected and the right motor (MI) cortex was electrically stimulated to produce predominantly left vibrissae movements. Animals were sacrificed and their brains autoradiographed. Right motor cortex (MI) stimulation activated subcortical structures bilaterally in 3 of 5 neonatally lesioned rats. Right MI stimulation activated most subcortical structures unilaterally in 30-day lesioned rats. This implies that a critical period for SM cortex injury may occur between 1 and 30 days of age. We suggest that removal of left SM cortex at 1 day of age occurs before or during the critical period and this induces right MI cortex to form bilateral subcortical connections. The bilateral 2DG uptake increases imply the bilateral connections are functional. The unilateral subcortical activation in 2 of 5 neonatally lesioned animals may have been due to differences in size of the lesion, parameters of stimulation, or perhaps due to the time of the lesion being near the critical period. We also suggest that removal of left SM cortex at 30 days of age occurs after the critical period, but that this does not affect the predominantly ipsilateral subcortical connections from MI cortex which have previously formed during normal development.

AB - The left sensorimotor (SM) cortex was removed in 1-day-old and 30-day-old rats. At 90 days of age [14C]2-deoxyglucose (2DG) was injected and the right motor (MI) cortex was electrically stimulated to produce predominantly left vibrissae movements. Animals were sacrificed and their brains autoradiographed. Right motor cortex (MI) stimulation activated subcortical structures bilaterally in 3 of 5 neonatally lesioned rats. Right MI stimulation activated most subcortical structures unilaterally in 30-day lesioned rats. This implies that a critical period for SM cortex injury may occur between 1 and 30 days of age. We suggest that removal of left SM cortex at 1 day of age occurs before or during the critical period and this induces right MI cortex to form bilateral subcortical connections. The bilateral 2DG uptake increases imply the bilateral connections are functional. The unilateral subcortical activation in 2 of 5 neonatally lesioned animals may have been due to differences in size of the lesion, parameters of stimulation, or perhaps due to the time of the lesion being near the critical period. We also suggest that removal of left SM cortex at 30 days of age occurs after the critical period, but that this does not affect the predominantly ipsilateral subcortical connections from MI cortex which have previously formed during normal development.

KW - 2-deoxyglucose

KW - motor cortex

KW - neonatal lesions

KW - plasticity

UR - http://www.scopus.com/inward/record.url?scp=0020371417&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020371417&partnerID=8YFLogxK

U2 - 10.1016/0165-3806(82)90168-7

DO - 10.1016/0165-3806(82)90168-7

M3 - Article

AN - SCOPUS:0020371417

VL - 6

SP - 1

EP - 11

JO - Developmental Brain Research

JF - Developmental Brain Research

SN - 0165-3806

IS - 1

ER -