Bilateral renal dysplasia with nephron hypoplasia in a foal.

S. C. Zicker, G. D. Marty, Gary Carlson, John E Madigan, J. M. Smith, B. W. Goetzman

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Bilateral renal dysplasia and nephron hypoplasia was diagnosed in a Quarter Horse foal with clinical signs of lethargy, convulsions, and diarrhea. Laboratory evaluation revealed anemia, hypoproteinemia, leukopenia, hyponatremia, hypochloremia, and hyposmolality. The foal also had high concentrations of serum creatinine, BUN, and phosphorus. Evaluation of urinary indices revealed a high ratio of urinary gamma-glutamyl-transferase activity to concentration of creatinine, as well as a high fractional clearance ratio of sodium and potassium. Intravenous treatment with saline solution (0.9% NaCl) and antimicrobials provided only temporary resolution of some of the abnormalities. Diagnosis was partly established by histologic evaluation of renal tissue obtained via an ultrasonographically guided biopsy and was confirmed at necropsy. Pathologic changes in the kidney were unique in that the size of the kidneys, along with the appearance and number of glomeruli, were essentially normal despite marked hypoplasia of nephron tubules in the medulla.

Original languageEnglish (US)
Pages (from-to)2001-2005
Number of pages5
JournalJournal of the American Veterinary Medical Association
Volume196
Issue number12
StatePublished - Jun 15 1990

ASJC Scopus subject areas

  • veterinary(all)

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