Bilateral midbrain transections block the behavioral effects of cholecystokinin on feeding and exploration in rats

Jacqueline Crawley; J. Z. Kiss; E. Mezey

doi:10.1016/0006-8993(84)90124-0

Bilateral midbrain transections block the behavioral effects of cholecystokinin on feeding and exploration in rats

Jacqueline Crawley, J. Z. Kiss, E. Mezey

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

The mechanism by which peripherally administered cholecystokinin (CCK) reduces feeding and exploration involves a sensory feedback pathway from the gastrointestinal regions, via the vagus nerve^7,22,31 through the nucleus tractus solitarius (NTS)⁹. Bilateral dorsal midbrain transections rostral to the NTS abolish the ability of CCK to reduce food consumption, decrease exploratory approaches, and increase pauses of behavioral inactivity, as compared to these actions of CCK in normal and sham-lesioned control rats, suggesting that ascending NTS fibers are a necessary component in this feedback system.

Original language	English (US)
Pages (from-to)	316-321
Number of pages	6
Journal	Brain Research
Volume	322
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(84)90124-0
State	Published - Nov 26 1984
Externally published	Yes

Keywords

CCK
exploratory behavior
feeding behavior
midbrain lesions

ASJC Scopus subject areas

Developmental Biology
Molecular Biology
Clinical Neurology
Neuroscience(all)

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10.1016/0006-8993(84)90124-0

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title = "Bilateral midbrain transections block the behavioral effects of cholecystokinin on feeding and exploration in rats",

abstract = "The mechanism by which peripherally administered cholecystokinin (CCK) reduces feeding and exploration involves a sensory feedback pathway from the gastrointestinal regions, via the vagus nerve7,22,31 through the nucleus tractus solitarius (NTS)9. Bilateral dorsal midbrain transections rostral to the NTS abolish the ability of CCK to reduce food consumption, decrease exploratory approaches, and increase pauses of behavioral inactivity, as compared to these actions of CCK in normal and sham-lesioned control rats, suggesting that ascending NTS fibers are a necessary component in this feedback system.",

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AU - Crawley, Jacqueline

AU - Kiss, J. Z.

AU - Mezey, E.

PY - 1984/11/26

Y1 - 1984/11/26

N2 - The mechanism by which peripherally administered cholecystokinin (CCK) reduces feeding and exploration involves a sensory feedback pathway from the gastrointestinal regions, via the vagus nerve7,22,31 through the nucleus tractus solitarius (NTS)9. Bilateral dorsal midbrain transections rostral to the NTS abolish the ability of CCK to reduce food consumption, decrease exploratory approaches, and increase pauses of behavioral inactivity, as compared to these actions of CCK in normal and sham-lesioned control rats, suggesting that ascending NTS fibers are a necessary component in this feedback system.

AB - The mechanism by which peripherally administered cholecystokinin (CCK) reduces feeding and exploration involves a sensory feedback pathway from the gastrointestinal regions, via the vagus nerve7,22,31 through the nucleus tractus solitarius (NTS)9. Bilateral dorsal midbrain transections rostral to the NTS abolish the ability of CCK to reduce food consumption, decrease exploratory approaches, and increase pauses of behavioral inactivity, as compared to these actions of CCK in normal and sham-lesioned control rats, suggesting that ascending NTS fibers are a necessary component in this feedback system.

KW - CCK

KW - exploratory behavior

KW - feeding behavior

KW - midbrain lesions

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Bilateral midbrain transections block the behavioral effects of cholecystokinin on feeding and exploration in rats

Abstract

Keywords

ASJC Scopus subject areas

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