Abstract
The mechanism by which peripherally administered cholecystokinin (CCK) reduces feeding and exploration involves a sensory feedback pathway from the gastrointestinal regions, via the vagus nerve7,22,31 through the nucleus tractus solitarius (NTS)9. Bilateral dorsal midbrain transections rostral to the NTS abolish the ability of CCK to reduce food consumption, decrease exploratory approaches, and increase pauses of behavioral inactivity, as compared to these actions of CCK in normal and sham-lesioned control rats, suggesting that ascending NTS fibers are a necessary component in this feedback system.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 316-321 |
| Number of pages | 6 |
| Journal | Brain Research |
| Volume | 322 |
| Issue number | 2 |
| DOIs | |
| State | Published - Nov 26 1984 |
| Externally published | Yes |
Keywords
- CCK
- exploratory behavior
- feeding behavior
- midbrain lesions
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
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Cite this
Crawley, J., Kiss, J. Z., & Mezey, E. (1984). Bilateral midbrain transections block the behavioral effects of cholecystokinin on feeding and exploration in rats. Brain Research, 322(2), 316-321. https://doi.org/10.1016/0006-8993(84)90124-0