Bifurcation and chaos in a model of cardiac early afterdepolarizations

Diana X. Tran, Daisuke Sato, Arik Yochelis, James N. Weiss, Alan Garfinkel, Zhilin Qu

Research output: Contribution to journalArticlepeer-review

99 Scopus citations


Excitable cells can exhibit complex patterns of oscillations, such as spiking and bursting. In cardiac cells, pathological voltage oscillations, called early afterdepolarizations (EADs), have been widely observed under disease conditions, yet their dynamical mechanisms remain unknown. Here, we show that EADs are caused by Hopf and homoclinic bifurcations. During period pacing, chaos always occurs at the transition from no EAD to EADs as the stimulation frequency decreases, providing a distinct explanation for the irregular EAD behavior frequently observed in experiments.

Original languageEnglish (US)
Article number258103
JournalPhysical Review Letters
Issue number25
StatePublished - Jun 25 2009

ASJC Scopus subject areas

  • Physics and Astronomy(all)


Dive into the research topics of 'Bifurcation and chaos in a model of cardiac early afterdepolarizations'. Together they form a unique fingerprint.

Cite this