Bifurcation and chaos in a model of cardiac early afterdepolarizations

Diana X. Tran, Daisuke Sato, Arik Yochelis, James N. Weiss, Alan Garfinkel, Zhilin Qu

Research output: Contribution to journalArticlepeer-review

85 Scopus citations

Abstract

Excitable cells can exhibit complex patterns of oscillations, such as spiking and bursting. In cardiac cells, pathological voltage oscillations, called early afterdepolarizations (EADs), have been widely observed under disease conditions, yet their dynamical mechanisms remain unknown. Here, we show that EADs are caused by Hopf and homoclinic bifurcations. During period pacing, chaos always occurs at the transition from no EAD to EADs as the stimulation frequency decreases, providing a distinct explanation for the irregular EAD behavior frequently observed in experiments.

Original languageEnglish (US)
Article number258103
JournalPhysical Review Letters
Volume102
Issue number25
DOIs
StatePublished - Jun 25 2009

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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