Bifunctional chelates for radiopharmaceutical labeling

D. A. Goodwin, C. F. Meares, C. I. Diamanti, M. W. Sundberg

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

The use of the first of a new class of chelating agents for the binding of metal ions to macromolecules as a novel approach to radiopharmaceutical labeling is described. Advantages are mild reaction conditions, large variety of accessible radionuclides and reactive groups, and separation of synthetic organic chemistry from radiochemistry. Human serum albumin and bovine fibrinogen labeled with 111Indium using this technique were relatively stable in vitro and in vivo, showed little alteration in function, and have potential as tumor localizing agents in humans.

Original languageEnglish (US)
Title of host publicationNUCL.MED.
Pages365-373
Number of pages9
Volume14
Edition4
StatePublished - 1975
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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