Bifunctional chelates for radio-pharmaceutical labeling.

D. A. Goodwin, C. F. Meares, C. I. Diamanti, M. W. Sundberg

Research output: Contribution to journalArticle

Abstract

The use of the first of a new class of chelating agents for the binding of metal ions to macromolecules as a novel approach to radiopharmaceutical labeling is described. Advantages are mild reaction conditions, large variety of accessible radionuclides and reactive groups, and separation of synthetic organic chemistry from radiochemistry. Human serum albumin and bovine fibrinogen labeled with 111Indium using this technique were relatively stable in vitro and in vivo, showed little alteration in function, and have potential as tumor localizing agents in humans.

Original languageEnglish (US)
Pages (from-to)365-373
Number of pages9
JournalNuklearmedizin
Volume14
Issue number4
StatePublished - Dec 15 1975
Externally publishedYes

Fingerprint

Radio
Radiochemistry
Organic Chemistry
Radiopharmaceuticals
Chelating Agents
Bovine Serum Albumin
Radioisotopes
Pharmaceutical Preparations
Fibrinogen
Ions
Neoplasms
In Vitro Techniques

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Goodwin, D. A., Meares, C. F., Diamanti, C. I., & Sundberg, M. W. (1975). Bifunctional chelates for radio-pharmaceutical labeling. Nuklearmedizin, 14(4), 365-373.

Bifunctional chelates for radio-pharmaceutical labeling. / Goodwin, D. A.; Meares, C. F.; Diamanti, C. I.; Sundberg, M. W.

In: Nuklearmedizin, Vol. 14, No. 4, 15.12.1975, p. 365-373.

Research output: Contribution to journalArticle

Goodwin, DA, Meares, CF, Diamanti, CI & Sundberg, MW 1975, 'Bifunctional chelates for radio-pharmaceutical labeling.', Nuklearmedizin, vol. 14, no. 4, pp. 365-373.
Goodwin DA, Meares CF, Diamanti CI, Sundberg MW. Bifunctional chelates for radio-pharmaceutical labeling. Nuklearmedizin. 1975 Dec 15;14(4):365-373.
Goodwin, D. A. ; Meares, C. F. ; Diamanti, C. I. ; Sundberg, M. W. / Bifunctional chelates for radio-pharmaceutical labeling. In: Nuklearmedizin. 1975 ; Vol. 14, No. 4. pp. 365-373.
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