Bidirectional role of β2-adrenergic receptor in autoimmune diseases

Li Wu, Yu Tai, Shanshan Hu, Mei Zhang, Rui Wang, Weijie Zhou, Juan Tao, Yongsheng Han, Qingtong Wang, Wei Wei

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Disorder of the sympathetic nervous system (SNS) is closely related to the pathogenesis of various autoimmune diseases (ADs). Catecholamine triggered beta2-adrenergic receptor (β2-AR) signaling is important in creating a bidirectional response in the progression of ADs due to factors including diverse expression patterns, single nucleotide polymorphisms (SNPs), biased signals, and desensitization of β2-AR, as well as different subtypes of Gα binding to β2-AR. In this review, we summarize the actions of β2-AR signaling in regulating the functions of immunocytes and in the pathogenesis of ADs, and the application of β2-AR agonists or antagonists in treating major types of ADs is also discussed. We suggest that restoring the immune balance via a soft regulation of the expression or activation of β2-AR is one of the promising therapeutic strategies for systematic ADs.

Original languageEnglish (US)
Article number01313
JournalFrontiers in Pharmacology
Issue numberNOV
StatePublished - Nov 27 2018
Externally publishedYes


  • Autoimmune diseases
  • Immune response
  • Single nucleotide polymorphisms
  • Soft regulation
  • β2-adrenergic receptor

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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