Bidirectional role of β2-adrenergic receptor in autoimmune diseases

Li Wu, Yu Tai, Shanshan Hu, Mei Zhang, Rui Wang, Weijie Zhou, Juan Tao, Yongsheng Han, Qingtong Wang, Wei Wei

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Disorder of the sympathetic nervous system (SNS) is closely related to the pathogenesis of various autoimmune diseases (ADs). Catecholamine triggered beta2-adrenergic receptor (β2-AR) signaling is important in creating a bidirectional response in the progression of ADs due to factors including diverse expression patterns, single nucleotide polymorphisms (SNPs), biased signals, and desensitization of β2-AR, as well as different subtypes of Gα binding to β2-AR. In this review, we summarize the actions of β2-AR signaling in regulating the functions of immunocytes and in the pathogenesis of ADs, and the application of β2-AR agonists or antagonists in treating major types of ADs is also discussed. We suggest that restoring the immune balance via a soft regulation of the expression or activation of β2-AR is one of the promising therapeutic strategies for systematic ADs.

Original languageEnglish (US)
Article number01313
JournalFrontiers in Pharmacology
Volume9
Issue numberNOV
DOIs
StatePublished - Nov 27 2018
Externally publishedYes

Fingerprint

Adrenergic Receptors
Autoimmune Diseases
Sympathetic Nervous System
Catecholamines
Single Nucleotide Polymorphism
Therapeutics

Keywords

  • Autoimmune diseases
  • Immune response
  • Single nucleotide polymorphisms
  • Soft regulation
  • β2-adrenergic receptor

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Wu, L., Tai, Y., Hu, S., Zhang, M., Wang, R., Zhou, W., ... Wei, W. (2018). Bidirectional role of β2-adrenergic receptor in autoimmune diseases. Frontiers in Pharmacology, 9(NOV), [01313]. https://doi.org/10.3389/fphar.2018.01313

Bidirectional role of β2-adrenergic receptor in autoimmune diseases. / Wu, Li; Tai, Yu; Hu, Shanshan; Zhang, Mei; Wang, Rui; Zhou, Weijie; Tao, Juan; Han, Yongsheng; Wang, Qingtong; Wei, Wei.

In: Frontiers in Pharmacology, Vol. 9, No. NOV, 01313, 27.11.2018.

Research output: Contribution to journalReview article

Wu, L, Tai, Y, Hu, S, Zhang, M, Wang, R, Zhou, W, Tao, J, Han, Y, Wang, Q & Wei, W 2018, 'Bidirectional role of β2-adrenergic receptor in autoimmune diseases', Frontiers in Pharmacology, vol. 9, no. NOV, 01313. https://doi.org/10.3389/fphar.2018.01313
Wu, Li ; Tai, Yu ; Hu, Shanshan ; Zhang, Mei ; Wang, Rui ; Zhou, Weijie ; Tao, Juan ; Han, Yongsheng ; Wang, Qingtong ; Wei, Wei. / Bidirectional role of β2-adrenergic receptor in autoimmune diseases. In: Frontiers in Pharmacology. 2018 ; Vol. 9, No. NOV.
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