Abstract
The L-arginine acts stereoselectively on the Pc1.LSU nuclear group I intron of Pneumocystis carinii, competitively inhibiting the first step of the splicing reaction and stimulating the second step. A number of arginine-related compounds are more potent than L-arginine as stimulators and inhibitors. The most potent peptides tested are 10,000 times as effective as L-arginine in inhibiting ribozyme activity, and nearly 400 times as effective as stimulators. This phenomenon indicates that ribozymes, like protein enzymes, can interact with non-substrate low molecular weight compounds, and that non-nucleic acid agents might be developed as drugs acting on RNA targets.
Original language | English (US) |
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Journal | The Journal of eukaryotic microbiology |
Volume | 41 |
Issue number | 5 |
State | Published - Sep 1994 |
Externally published | Yes |
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Agricultural and Biological Sciences (miscellaneous)
- Applied Microbiology and Biotechnology
- Microbiology