Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes

Pratima Thakur, Sepehr Dadsetan, Alla F Fomina

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: Ryanodine receptors (RyR) are intracellular Ca2+ release channels. Results: RyR are expressed in human T cells. Modulating the RyR activity in human T cells affects Ca2+ leakage from the store and store-operated Ca2+ entry. Conclusion: RyR strongly regulate Ca 2+ influx in human T cells. Significance: RyR can be used as a target for manipulating immune responses in humans.

Original languageEnglish (US)
Pages (from-to)37233-37244
Number of pages12
JournalJournal of Biological Chemistry
Volume287
Issue number44
DOIs
StatePublished - Oct 26 2012

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Ryanodine Receptor Calcium Release Channel
T-cells
Machinery
T-Lymphocytes
Human Activities

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

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abstract = "Background: Ryanodine receptors (RyR) are intracellular Ca2+ release channels. Results: RyR are expressed in human T cells. Modulating the RyR activity in human T cells affects Ca2+ leakage from the store and store-operated Ca2+ entry. Conclusion: RyR strongly regulate Ca 2+ influx in human T cells. Significance: RyR can be used as a target for manipulating immune responses in humans.",
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AU - Dadsetan, Sepehr

AU - Fomina, Alla F

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N2 - Background: Ryanodine receptors (RyR) are intracellular Ca2+ release channels. Results: RyR are expressed in human T cells. Modulating the RyR activity in human T cells affects Ca2+ leakage from the store and store-operated Ca2+ entry. Conclusion: RyR strongly regulate Ca 2+ influx in human T cells. Significance: RyR can be used as a target for manipulating immune responses in humans.

AB - Background: Ryanodine receptors (RyR) are intracellular Ca2+ release channels. Results: RyR are expressed in human T cells. Modulating the RyR activity in human T cells affects Ca2+ leakage from the store and store-operated Ca2+ entry. Conclusion: RyR strongly regulate Ca 2+ influx in human T cells. Significance: RyR can be used as a target for manipulating immune responses in humans.

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