Bicuculline methiodide in the blood-brain barrier - epileptogen model of epilepsy

M. P. Remler, W. H. Marcussen

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Focal epilepsy can be produced by a blood-brain barrier (BBB)-excluded systemic convulsant (penicillin, folic acid, etc.) in the presence of a focal BBB lesion. Bicuculline methiodide, a γ-aminobutyric acid blocking epileptogen, crosses the normal BBB of rats poorly and produces no consistent abnormality behaviorally or on EEG of 36 mg/kg. When the BBB is opened in 0.25 ml of cortex by 6,000 rad of α particles, by a pin trauma lesion, or by a heat lesion, the rats are normal clinically and on EEG. When these lesioned rats are challenged with bicuculline methiodide, 36 mg/kg, an intense, highly localized epileptiform discharge results that begins ~20 min after injection and lasts 30-90 min. The plausibility and experimental utility of the BBB-epileptogen model of epilepsy are enhanced by these observations.

Original languageEnglish (US)
Pages (from-to)69-73
Number of pages5
Issue number1
StatePublished - 1985

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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