Bicuculline attenuates the MLR-induced suppression of dorsal horn neurons receiving group III afferent input

Alexandr M. Degtyarenko; Marc P Kaufman

doi:10.1016/S0006-8993(02)02418-6

Bicuculline attenuates the MLR-induced suppression of dorsal horn neurons receiving group III afferent input

Alexandr M. Degtyarenko, Marc P Kaufman

Cardiovascular Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

In decerebrate cats, we found that iontophoretic application of bicuculline, a GABA_A receptor antagonist, attenuated the mesencephalic locomotor region-induced suppression of dorsal horn neurons responding to group III afferent input from the hindlimb. Our findings raise the possibility that GABA release onto dorsal horn neurons in the spinal cord may play an important role in the attenuation of the exercise pressor reflex by central command during exercise.

Original language	English (US)
Pages (from-to)	109-113
Number of pages	5
Journal	Brain Research
Volume	935
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(02)02418-6
State	Published - May 10 2002

Keywords

Cat
Central command
Exercise
GABA

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Developmental Biology
Clinical Neurology

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10.1016/S0006-8993(02)02418-6

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abstract = "In decerebrate cats, we found that iontophoretic application of bicuculline, a GABAA receptor antagonist, attenuated the mesencephalic locomotor region-induced suppression of dorsal horn neurons responding to group III afferent input from the hindlimb. Our findings raise the possibility that GABA release onto dorsal horn neurons in the spinal cord may play an important role in the attenuation of the exercise pressor reflex by central command during exercise.",

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AB - In decerebrate cats, we found that iontophoretic application of bicuculline, a GABAA receptor antagonist, attenuated the mesencephalic locomotor region-induced suppression of dorsal horn neurons responding to group III afferent input from the hindlimb. Our findings raise the possibility that GABA release onto dorsal horn neurons in the spinal cord may play an important role in the attenuation of the exercise pressor reflex by central command during exercise.

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KW - Exercise

KW - GABA

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Bicuculline attenuates the MLR-induced suppression of dorsal horn neurons receiving group III afferent input

Abstract

Keywords

ASJC Scopus subject areas

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