Bicuculline attenuates the MLR-induced suppression of dorsal horn neurons receiving group III afferent input

Alexandr M. Degtyarenko, Marc P Kaufman

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

In decerebrate cats, we found that iontophoretic application of bicuculline, a GABAA receptor antagonist, attenuated the mesencephalic locomotor region-induced suppression of dorsal horn neurons responding to group III afferent input from the hindlimb. Our findings raise the possibility that GABA release onto dorsal horn neurons in the spinal cord may play an important role in the attenuation of the exercise pressor reflex by central command during exercise.

Original languageEnglish (US)
Pages (from-to)109-113
Number of pages5
JournalBrain Research
Volume935
Issue number1-2
DOIs
StatePublished - May 10 2002

Keywords

  • Cat
  • Central command
  • Exercise
  • GABA

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Developmental Biology
  • Clinical Neurology

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