Biaxial elastic properties of rat arteries in vivo: Influence of vascular wall cells on anisotropy

G. J. L'Italien, N. R. Chandrasekar, G. M. Lamuraglia, William C Pevec, S. Dhara, D. F. Warnock, W. M. Abbott

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

There is no consensus as to the degree of arterial anisotropy or to its relationship to vascular cell function. Given the relevance of the isotropic assumption in formulating elasticity models, reliable measures of biaxial displacements are needed. In this study, a video motion analyzer (VMA) was used to describe the biaxial in vivo dynamic elasticity of 22 carotid arteries and 5 abdominal aortas in 27 rats. The influence of vascular cell function was also examined by subjecting six rats to a photosensitive drug, chloroaluminum sulfonated phthalocyanine (CASPc), which is focally cytotoxic on activation by laser. Circumferential compliance (C(circ)) was greater than longitudinal compliance (C(long)) for all vessels. Compliance pressure curves were nonlinear, and biaxial displacements were in phase. The circumferential elastic modulus was less than the longitudinal modulus at common stresses. CASPc + laser reduced C(circ) but not C(long), thus altering Poisson's ratio. In conclusion, rat arteries are biaxially, nonlinearly elastic and anisotropic in vivo. Vascular cells modulate Poisson's ratio by influencing C(circ).

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume267
Issue number2 36-2
StatePublished - 1994
Externally publishedYes

Fingerprint

Anisotropy
Cell Wall
Compliance
Blood Vessels
Arteries
Elasticity
Lasers
Elastic Modulus
Abdominal Aorta
Carotid Arteries
Pressure
Pharmaceutical Preparations
chloroaluminum phthalocyanine

Keywords

  • biaxial elasticity
  • compliance
  • vascular tone

ASJC Scopus subject areas

  • Physiology

Cite this

L'Italien, G. J., Chandrasekar, N. R., Lamuraglia, G. M., Pevec, W. C., Dhara, S., Warnock, D. F., & Abbott, W. M. (1994). Biaxial elastic properties of rat arteries in vivo: Influence of vascular wall cells on anisotropy. American Journal of Physiology - Heart and Circulatory Physiology, 267(2 36-2).

Biaxial elastic properties of rat arteries in vivo : Influence of vascular wall cells on anisotropy. / L'Italien, G. J.; Chandrasekar, N. R.; Lamuraglia, G. M.; Pevec, William C; Dhara, S.; Warnock, D. F.; Abbott, W. M.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 267, No. 2 36-2, 1994.

Research output: Contribution to journalArticle

L'Italien, GJ, Chandrasekar, NR, Lamuraglia, GM, Pevec, WC, Dhara, S, Warnock, DF & Abbott, WM 1994, 'Biaxial elastic properties of rat arteries in vivo: Influence of vascular wall cells on anisotropy', American Journal of Physiology - Heart and Circulatory Physiology, vol. 267, no. 2 36-2.
L'Italien, G. J. ; Chandrasekar, N. R. ; Lamuraglia, G. M. ; Pevec, William C ; Dhara, S. ; Warnock, D. F. ; Abbott, W. M. / Biaxial elastic properties of rat arteries in vivo : Influence of vascular wall cells on anisotropy. In: American Journal of Physiology - Heart and Circulatory Physiology. 1994 ; Vol. 267, No. 2 36-2.
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