Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice

Scott C. Kogan, Jerrold M. Ward, Miriam R. Anver, Jules J. Berman, Cory Brayton, Robert Cardiff, John S. Carter, Sherri De Coronado, James R. Downing, Torgny N. Fredrickson, Diana C. Haines, Alan W. Harris, Nancy Lee Harris, Hiroshi Hiai, Elaine S. Jaffe, Ian C.M. MacLennan, Pier Paolo Pandolfi, Paul K. Pattengale, Archibald S. Perkins, R. Mark SimpsonMark S. Tuttle, Joanne F. Wong, Herbert C. Morse

Research output: Contribution to journalArticle

305 Citations (Scopus)

Abstract

The hematopathology subcommittee of the Mouse Models of Human Cancers Consortium recognized the need for a classification of murine hematopoietic neoplasms that would allow investigators to diagnose lesions as well-defined entities according to accepted criteria. Pathologists and investigators worked cooperatively to develop proposals for the classification of lymphoid and nonlymphoid hematopoietic neoplasms. It is proposed here that nonlymphoid hematopoietic neoplasms of mice be classified in 4 broad categories: nonlymphoid leukemias, nonlymphoid hematopoietic sarcomas, myeloid dysplasias, and myeloid proliferations (nonreactive). Criteria for diagnosis and subclassification of these lesions include peripheral blood findings, cytologic features of hematopoietic tissues, histopathology, immunophenotyping, genetic features, and clinical course. Differences between murine and human lesions are reflected in the terminology and methods used for classification. This classification will be of particular value to investigators seeking to develop, use, and communicate about mouse models of human hematopoietic neoplasms.

Original languageEnglish (US)
Pages (from-to)238-245
Number of pages8
JournalBlood
Volume100
Issue number1
DOIs
StatePublished - Jul 1 2002

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Hematologic Neoplasms
Research Personnel
Myeloid Sarcoma
Immunophenotyping
Terminology
Leukemia
Blood
Tissue
Neoplasms

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Kogan, S. C., Ward, J. M., Anver, M. R., Berman, J. J., Brayton, C., Cardiff, R., ... Morse, H. C. (2002). Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice. Blood, 100(1), 238-245. https://doi.org/10.1182/blood.V100.1.238

Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice. / Kogan, Scott C.; Ward, Jerrold M.; Anver, Miriam R.; Berman, Jules J.; Brayton, Cory; Cardiff, Robert; Carter, John S.; De Coronado, Sherri; Downing, James R.; Fredrickson, Torgny N.; Haines, Diana C.; Harris, Alan W.; Harris, Nancy Lee; Hiai, Hiroshi; Jaffe, Elaine S.; MacLennan, Ian C.M.; Pandolfi, Pier Paolo; Pattengale, Paul K.; Perkins, Archibald S.; Mark Simpson, R.; Tuttle, Mark S.; Wong, Joanne F.; Morse, Herbert C.

In: Blood, Vol. 100, No. 1, 01.07.2002, p. 238-245.

Research output: Contribution to journalArticle

Kogan, SC, Ward, JM, Anver, MR, Berman, JJ, Brayton, C, Cardiff, R, Carter, JS, De Coronado, S, Downing, JR, Fredrickson, TN, Haines, DC, Harris, AW, Harris, NL, Hiai, H, Jaffe, ES, MacLennan, ICM, Pandolfi, PP, Pattengale, PK, Perkins, AS, Mark Simpson, R, Tuttle, MS, Wong, JF & Morse, HC 2002, 'Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice', Blood, vol. 100, no. 1, pp. 238-245. https://doi.org/10.1182/blood.V100.1.238
Kogan, Scott C. ; Ward, Jerrold M. ; Anver, Miriam R. ; Berman, Jules J. ; Brayton, Cory ; Cardiff, Robert ; Carter, John S. ; De Coronado, Sherri ; Downing, James R. ; Fredrickson, Torgny N. ; Haines, Diana C. ; Harris, Alan W. ; Harris, Nancy Lee ; Hiai, Hiroshi ; Jaffe, Elaine S. ; MacLennan, Ian C.M. ; Pandolfi, Pier Paolo ; Pattengale, Paul K. ; Perkins, Archibald S. ; Mark Simpson, R. ; Tuttle, Mark S. ; Wong, Joanne F. ; Morse, Herbert C. / Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice. In: Blood. 2002 ; Vol. 100, No. 1. pp. 238-245.
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