Beta Adrenergic Receptors in Keratinocytes

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Beta2 adrenergic receptors were identified in keratinocytes more than 30 years ago, but their function in the epidermis continues to be elucidated. Abnormalities in their expression, signaling pathway, or in the generation of endogenous catecholamine agonists by keratinocytes have been implicated in the pathogenesis of cutaneous diseases such as atopic dermatitis, vitiligo, and psoriasis. New studies also indicate that the beta2AR also modulates keratinocyte migration, and thus can function to regulate wound reepithelialization. This review focuses on the function of these receptors in keratinocytes and their contribution to cutaneous physiology and disease.

Original languageEnglish (US)
Pages (from-to)643-653
Number of pages11
JournalDermatologic Clinics
Volume25
Issue number4
DOIs
StatePublished - Oct 2007

ASJC Scopus subject areas

  • Dermatology

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