Abstract
Maddock Richard J., Evanne J. Casson, Lori A. Lott, Cameron S. Carter, and Chris A. Johnson: Benzodiazepine effects on flicker sensitivity: Role of stimulus frequency and size. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1993, 17(6): 955-970. 1. 1. Benzodiazepines (BZDs) impair sensitivity to temporally modulated visual stimuli (flicker). Critical flicker-fusion frequency (CFF) is commonly used as a measure of this effect, but it only measures sensitivity to a narrow range of frequencies, usually above 25 Hz. Are other frequencies more sensitive to the effects of BZDs? 2. 2. Flicker sensitivity at 1, 2, 4, 8, 16, and 32 Hz was measured for 1° and 5° stimuli before and 50 to 100 minutes after triazolam (0.25 mg), lorazepam (1.0 mg) and placebo. Drug effects on CFF were also measured. 3. 3. Both BZDs significantly impaired overall flicker sensitivity. Triazolam produced 50% more impairment than lorazepam. CFF was significantly impaired by triazolam. BZD effects did not vary with stimulus size. 4. 4. Significantly greater BZD-induced impairment of flicker sensitivity occurred at 16 Hz than at 1, 2, 4, or 32 Hz. 5. 5. The magnitude of BZD effects on flicker sensitivity vary with the temporal frequency of the stimulus. BZD effects are greatest for 8-16 Hz stimuli.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 955-970 |
| Number of pages | 16 |
| Journal | Progress in Neuropsychopharmacology and Biological Psychiatry |
| Volume | 17 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1993 |
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Keywords
- benzodiazepines
- CFF
- flicker
- lorazepam
- triazolam
ASJC Scopus subject areas
- Biological Psychiatry
- Pharmacology
Cite this
Benzodiazepine effects on flicker sensitivity : Role of stimulus frequency and size. / Maddock, Richard J; Casson, Evanne J.; Lott, Lori A.; Carter, Cameron S; Johnson, Chris A.
In: Progress in Neuropsychopharmacology and Biological Psychiatry, Vol. 17, No. 6, 1993, p. 955-970.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Benzodiazepine effects on flicker sensitivity
T2 - Role of stimulus frequency and size
AU - Maddock, Richard J
AU - Casson, Evanne J.
AU - Lott, Lori A.
AU - Carter, Cameron S
AU - Johnson, Chris A.
PY - 1993
Y1 - 1993
N2 - Maddock Richard J., Evanne J. Casson, Lori A. Lott, Cameron S. Carter, and Chris A. Johnson: Benzodiazepine effects on flicker sensitivity: Role of stimulus frequency and size. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1993, 17(6): 955-970. 1. 1. Benzodiazepines (BZDs) impair sensitivity to temporally modulated visual stimuli (flicker). Critical flicker-fusion frequency (CFF) is commonly used as a measure of this effect, but it only measures sensitivity to a narrow range of frequencies, usually above 25 Hz. Are other frequencies more sensitive to the effects of BZDs? 2. 2. Flicker sensitivity at 1, 2, 4, 8, 16, and 32 Hz was measured for 1° and 5° stimuli before and 50 to 100 minutes after triazolam (0.25 mg), lorazepam (1.0 mg) and placebo. Drug effects on CFF were also measured. 3. 3. Both BZDs significantly impaired overall flicker sensitivity. Triazolam produced 50% more impairment than lorazepam. CFF was significantly impaired by triazolam. BZD effects did not vary with stimulus size. 4. 4. Significantly greater BZD-induced impairment of flicker sensitivity occurred at 16 Hz than at 1, 2, 4, or 32 Hz. 5. 5. The magnitude of BZD effects on flicker sensitivity vary with the temporal frequency of the stimulus. BZD effects are greatest for 8-16 Hz stimuli.
AB - Maddock Richard J., Evanne J. Casson, Lori A. Lott, Cameron S. Carter, and Chris A. Johnson: Benzodiazepine effects on flicker sensitivity: Role of stimulus frequency and size. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1993, 17(6): 955-970. 1. 1. Benzodiazepines (BZDs) impair sensitivity to temporally modulated visual stimuli (flicker). Critical flicker-fusion frequency (CFF) is commonly used as a measure of this effect, but it only measures sensitivity to a narrow range of frequencies, usually above 25 Hz. Are other frequencies more sensitive to the effects of BZDs? 2. 2. Flicker sensitivity at 1, 2, 4, 8, 16, and 32 Hz was measured for 1° and 5° stimuli before and 50 to 100 minutes after triazolam (0.25 mg), lorazepam (1.0 mg) and placebo. Drug effects on CFF were also measured. 3. 3. Both BZDs significantly impaired overall flicker sensitivity. Triazolam produced 50% more impairment than lorazepam. CFF was significantly impaired by triazolam. BZD effects did not vary with stimulus size. 4. 4. Significantly greater BZD-induced impairment of flicker sensitivity occurred at 16 Hz than at 1, 2, 4, or 32 Hz. 5. 5. The magnitude of BZD effects on flicker sensitivity vary with the temporal frequency of the stimulus. BZD effects are greatest for 8-16 Hz stimuli.
KW - benzodiazepines
KW - CFF
KW - flicker
KW - lorazepam
KW - triazolam
UR - http://www.scopus.com/inward/record.url?scp=0027432526&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027432526&partnerID=8YFLogxK
U2 - 10.1016/0278-5846(93)90023-L
DO - 10.1016/0278-5846(93)90023-L
M3 - Article
C2 - 8278605
AN - SCOPUS:0027432526
VL - 17
SP - 955
EP - 970
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
SN - 0278-5846
IS - 6
ER -