Bending membranes on demand: Fluid phospholipid bilayers on topographically deformable substrates

Babak Sanii, Andreia Michelle Smith, Ravichandra Butti, Adrian M. Brozell, Atul N. Parikh

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

We combine hierarchical surface wrinkling of elastomers with lipid membrane deposition techniques to dynamically template complex three-dimensional topographies onto supported lipid bilayers. The real-time introduction of corresponding nano- to micrometer scale curvatures triggers spatially periodic, elastic bending of the bilayer, accompanied by molecular-level reorganizations. This ability to dynamically impose curvatures on supported bilayers and the ensuing re-equilibration promises fundamental material and biophysical investigations of curvature-dependent, static heterogeneities and dynamic reorganizations pervasive in biological membranes.

Original languageEnglish (US)
Pages (from-to)866-871
Number of pages6
JournalNano Letters
Volume8
Issue number3
DOIs
StatePublished - Mar 2008

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanical Engineering
  • Electronic, Optical and Magnetic Materials
  • Chemistry (miscellaneous)

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    Sanii, B., Smith, A. M., Butti, R., Brozell, A. M., & Parikh, A. N. (2008). Bending membranes on demand: Fluid phospholipid bilayers on topographically deformable substrates. Nano Letters, 8(3), 866-871. https://doi.org/10.1021/nl073085b