Bench to bedside: Tumor necrosis factor-alpha: From inflammation to resuscitation

C. B. Cairns, Edward A Panacek, A. H. Harken, A. Banerjee

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Proinflammatory mediators such as tumor necrosis factor-alpha (TNF) have been implicated in the pathophysiology in a number of acute disease states. Tumor necrosis factor-alpha can contribute to cell death, apoptosis, and organ dysfunction. Tumor necrosis factor-alpha can be generated with sepsis or ischemia-reperfusion by activation of cell mitogen-activated protein kinases and nuclear factor kappa B, leading to TNF production. A number of strategies to modulate TNF have been recently explored, including factors directed toward mitogen-activated protein kinases, TNF transcription, anti-inflammatory ligands, heat shock proteins, and TNF-binding proteins. However, TNF may also play an important role in the adaptive response to injury and inflammation. Control of the deleterious effects of TNF and other proinflammatory cytokines represents a realistic goal for clinical emergency medicine. The purpose of this article is to provide a background of relevance to emergency medicine academicians on the production and regulation of TNF, the acute effects of TNF on pathophysiology, and the rationale for therapeutic interventions directed toward TNF and the clinical experience with these strategies.

Original languageEnglish (US)
Pages (from-to)930-941
Number of pages12
JournalAcademic Emergency Medicine
Volume7
Issue number8
StatePublished - 2000

Fingerprint

Resuscitation
Tumor Necrosis Factor-alpha
Inflammation
Emergency Medicine
Mitogen-Activated Protein Kinases
NF-kappa B
Clinical Medicine
Acute Disease
Heat-Shock Proteins
Reperfusion
Sepsis
Carrier Proteins
Cell Death
Anti-Inflammatory Agents
Ischemia
Apoptosis
Cytokines
Ligands

Keywords

  • Emergency
  • Ischemia and reperfusion
  • Review
  • Sepsis
  • Shock
  • Therapy
  • Trauma
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Emergency Medicine

Cite this

Bench to bedside : Tumor necrosis factor-alpha: From inflammation to resuscitation. / Cairns, C. B.; Panacek, Edward A; Harken, A. H.; Banerjee, A.

In: Academic Emergency Medicine, Vol. 7, No. 8, 2000, p. 930-941.

Research output: Contribution to journalArticle

Cairns, C. B. ; Panacek, Edward A ; Harken, A. H. ; Banerjee, A. / Bench to bedside : Tumor necrosis factor-alpha: From inflammation to resuscitation. In: Academic Emergency Medicine. 2000 ; Vol. 7, No. 8. pp. 930-941.
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