Being "penny-wise but pound foolish" in cancer immunotherapy research: The urgent need for mouse cancer models to reflect human modifying factors

Research output: Contribution to journalComment/debate

3 Scopus citations

Abstract

Inbred mice are the mainstay for preclinical cancer assessment of potential therapeutics, especially immune-based approaches. However, the use of young, lean, inbred mice housed under specific-pathogen-free conditions does not mirror the human cancer scenario. This commentary discusses some of the issues in evaluating immunotherapeutics in mice given recent advances.

Original languageEnglish (US)
Article number88
JournalJournal for ImmunoTherapy of Cancer
Volume4
Issue number1
DOIs
StatePublished - Dec 20 2016

ASJC Scopus subject areas

  • Oncology
  • Immunology and Allergy
  • Cancer Research
  • Molecular Medicine
  • Pharmacology
  • Immunology

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