Behavioral regulation in methamphetamine abusers: An fMRI study

Ruth Salo, Catherine Fassbender, Michael H. Buonocore, Stefan Ursu

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


The goal of this study was to extend our previous findings of abnormal prefrontal function in methamphetamine (MA) abusers and controls and to link the imaging data to behavioral, demographic and drug use variables. We used a fast event-related functional magnetic resonance imaging (fMRI) design to examine trial-to-trial reaction time (RT) adjustments in 30 MA abusers and 30 controls. A variant of the Stroop task was employed to measure influence of response conflict on RT, including the level of trial-to-trial RT adjustments seen after conflict trials. Compared to control subjects, MA abusers exhibited reduced RT adjustments and reduced activation in the prefrontal cortex (PFC) after conflict trials. RT adjustment correlated negatively with PFC brain activity in the MA group, while a trend for a positive correlation was observed in controls. No correlations were observed between task performance or brain activity and age, education or drug use variables. These data support our previous findings that the ability to adapt a behavioral response based on prior experience is compromised in MA abusers. Interestingly, these impairments do not appear to be linked to drug use patterns or to educational levels.

Original languageEnglish (US)
Pages (from-to)234-238
Number of pages5
JournalPsychiatry Research - Neuroimaging
Issue number3
StatePublished - Mar 30 2013


  • Cognitive control
  • Functional magnetic resonance imaging (fMRI)
  • Imaging
  • Methamphetamine
  • Prefrontal

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Neuroscience (miscellaneous)


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