Behavioral recovery following sub-chronic paeoniflorin administration in the striatal 6-OHDA lesion rodent model of Parkinson's disease

Da Liu, Jun Zhu, Dao Zhong Jin, Li Min Zhang, Xin Quan Ji, Yang Ye, Chun Ping Tang, Xing Zu Zhu

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

In the present studies, the effect of paeoniflorin (PF), one of the main compounds extracted from Paeoniae radix, in alleviating the neurological impairment following unilateral striatal 6-hydroxydopamine (6-OHDA) lesion was examined in Sprague-Dawley rats. Sub-chronic PF (2.5, 5 and 10 mg/kg, s.c., twice daily for 11 days) administration dose-dependently reduced apomorphine (APO)-induced rotation, suggesting that PF had an ameliorative effect on the 6-OHDA-induced neurological impairment. Notably, PF had no direct action on dopamine D1 receptor or dopamine D2 receptor indicated by the competitive binding experiments. These results suggest that PF, an active component of Paeoniae radix, might provide an opportunity to introduce a non-dopaminergic management of Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)327-332
Number of pages6
JournalJournal of Ethnopharmacology
Volume112
Issue number2
DOIs
StatePublished - Jun 13 2007
Externally publishedYes

Keywords

  • Adenosine A receptor
  • Behavior recovery
  • Non-dopaminergic approach
  • Paeoniae radix
  • Paeoniflorin
  • Parkinson's disease
  • Striatal 6-hydroxydopamine-lesion rat

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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