Genomics is the buzzword of 21st-century biomedical research. Full sequencing of the human and mouse genomes is nearly complete. What do each of these 40 000 genes do? How do we begin to understand genes that mediate behaviors, physiology, anatomy, biochemistry, pharmacological responses and inherited diseases? The mouse has emerged as the mammalian organism of choice to explore the functions of individual genes that are relevant to human disorders. Experimental manipulation of the mouse genome is now practical via techniques including targeted gene mutations, chemical mutagenesis and in vivo gene delivery. Effective application of this new technology depends on our ability to detect phenotypic changes in the genetically altered mouse. This article describes approaches to optimize behavioral phenotyping, the characterization of behavioral traits, in mutant mice.
|Original language||English (US)|
|Number of pages||5|
|Journal||Trends in Ecology and Evolution|
|Issue number||SPEC. ISS.|
|State||Published - 2000|
ASJC Scopus subject areas
- Ecology, Evolution, Behavior and Systematics