Behavioral phenotyping of mutant mice

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Genomics is the buzzword of 21st-century biomedical research. Full sequencing of the human and mouse genomes is nearly complete. What do each of these 40 000 genes do? How do we begin to understand genes that mediate behaviors, physiology, anatomy, biochemistry, pharmacological responses and inherited diseases? The mouse has emerged as the mammalian organism of choice to explore the functions of individual genes that are relevant to human disorders. Experimental manipulation of the mouse genome is now practical via techniques including targeted gene mutations, chemical mutagenesis and in vivo gene delivery. Effective application of this new technology depends on our ability to detect phenotypic changes in the genetically altered mouse. This article describes approaches to optimize behavioral phenotyping, the characterization of behavioral traits, in mutant mice.

Original languageEnglish (US)
Pages (from-to)18-22
Number of pages5
JournalTrends in Ecology and Evolution
Issue numberSPEC. ISS.
StatePublished - 2000
Externally publishedYes

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phenotype
mutants
gene
mice
genes
genome
biochemistry
biomedical research
twenty first century
gene transfer
mutagenesis
anatomy
physiology
mutation
genomics
mutant
organisms
methodology

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics

Cite this

Behavioral phenotyping of mutant mice. / Crawley, Jacqueline.

In: Trends in Ecology and Evolution, No. SPEC. ISS., 2000, p. 18-22.

Research output: Contribution to journalArticle

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