Behavioral Phenotyping Assays for Genetic Mouse Models of Neurodevelopmental, Neurodegenerative, and Psychiatric Disorders

Stacey J. Sukoff Rizzo, Jacqueline Crawley

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

Animal models offer heuristic research tools to understand the causes of human diseases and to identify potential treatments. With rapidly evolving genetic engineering technologies, mutations identified in a human disorder can be generated in the mouse genome. Phenotypic outcomes of the mutation are then explicated to confirm hypotheses about causes and to discover effective therapeutics. Most neurodevelopmental, neurodegenerative, and psychiatric disorders are diagnosed primarily by their prominent behavioral symptoms. Mouse behavioral assays analogous to the human symptoms have been developed to analyze the consequences of mutations and to evaluate proposed therapeutics preclinically. Here we describe the range of mouse behavioral tests available in the established behavioral neuroscience literature, along with examples of their translational applications. Concepts presented have been successfully used in other species, including flies, worms, fish, rats, pigs, and nonhuman primates. Identical strategies can be employed to test hypotheses about environmental causes and gene × environment interactions.

Original languageEnglish (US)
Pages (from-to)371-389
Number of pages19
JournalAnnual Review of Animal Biosciences
Volume5
DOIs
StatePublished - Feb 8 2017

Keywords

  • Behavior
  • Genetics
  • Knockout
  • Mouse
  • Neurodegenerative
  • Neurodevelopmental
  • Phenotype
  • Psychiatric
  • Transgenic

ASJC Scopus subject areas

  • Biotechnology
  • Animal Science and Zoology
  • Genetics
  • veterinary(all)

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