Behavioral phenotype of fragile X syndrome in adolescence and adulthood

Leann E. Smith, Erin T. Barker, Marsha Mailick Seltzer, Leonard J Abbeduto, Jan S. Greenberg

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

The present study explored the behavioral profile of individuals with fragile X syndrome during adolescence and adulthood. Individuals with both fragile X syndrome and autism (n 5 30) were compared with (a) individuals diagnosed with fragile X syndrome (but not autism; n 5 106) and (b) individuals diagnosed with autism (but not fragile X syndrome; n 5 135) on measures of autism symptoms, adaptive functioning, behavior problems, and psychological symptoms. Results indicated that individuals dually diagnosed with fragile X syndrome and autism displayed greater communication and social reciprocity impairments than individuals with fragile X syndrome only. Individuals in the dually diagnosed group also exhibited higher levels of repetitive and challenging behaviors than either comparison group, suggesting a unique profile of vulnerability for those diagnosed with both fragile X syndrome and autism.

Original languageEnglish (US)
Pages (from-to)1-17
Number of pages17
JournalAmerican Journal on Intellectual and Developmental Disabilities
Volume117
Issue number1
DOIs
StatePublished - Jan 2012
Externally publishedYes

Keywords

  • Adolescence
  • Adulthood
  • Autism
  • Fragile X syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Psychiatry and Mental health
  • Developmental and Educational Psychology
  • Neuropsychology and Physiological Psychology
  • Arts and Humanities (miscellaneous)

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