Abstract
The orbital frontal cortex (OFC) has been implicated in a number of psychiatric disorders, including depression, anxiety, phobia, and obsessive-compulsive disorder. Thus, a better understanding of its functions will likely provide critical information to understand the specific behavioral and cognitive processes affected in these human disorders. In recent years, a growing number of studies have provided evidence for anatomical and functional differentiation within the OFC. Here we discuss the effects of selective OFC (areas 11/13) lesions on social behavior, emotional regulation, and behavioral adaptation. Damage to these specific OFC subfields in adult monkeys resulted in profound changes in the flexible modulation of responses guided by reward value that could explain the poor fear regulation and disturbed social interactions observed in the same animals. A similar pattern of results was found when the OFC lesions were done in infancy. Thus, in monkeys, self-regulation abilities mediated by OFC areas 11/13 emerge from midinfancy through adolescence.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 71-86 |
| Number of pages | 16 |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 1239 |
| Issue number | 1 |
| DOIs | |
| State | Published - Dec 2011 |
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Keywords
- Behavior
- Emotion
- Flexibility
- Orbitofrontal cortex
- Rhesus
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- History and Philosophy of Science
Cite this
Behavioral outcomes of late-onset or early-onset orbital frontal cortex (areas 11/13) lesions in rhesus monkeys. / Bachevalier, Jocelyne; Machado, Christopher J.; Kazama, Andy.
In: Annals of the New York Academy of Sciences, Vol. 1239, No. 1, 12.2011, p. 71-86.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Behavioral outcomes of late-onset or early-onset orbital frontal cortex (areas 11/13) lesions in rhesus monkeys
AU - Bachevalier, Jocelyne
AU - Machado, Christopher J.
AU - Kazama, Andy
PY - 2011/12
Y1 - 2011/12
N2 - The orbital frontal cortex (OFC) has been implicated in a number of psychiatric disorders, including depression, anxiety, phobia, and obsessive-compulsive disorder. Thus, a better understanding of its functions will likely provide critical information to understand the specific behavioral and cognitive processes affected in these human disorders. In recent years, a growing number of studies have provided evidence for anatomical and functional differentiation within the OFC. Here we discuss the effects of selective OFC (areas 11/13) lesions on social behavior, emotional regulation, and behavioral adaptation. Damage to these specific OFC subfields in adult monkeys resulted in profound changes in the flexible modulation of responses guided by reward value that could explain the poor fear regulation and disturbed social interactions observed in the same animals. A similar pattern of results was found when the OFC lesions were done in infancy. Thus, in monkeys, self-regulation abilities mediated by OFC areas 11/13 emerge from midinfancy through adolescence.
AB - The orbital frontal cortex (OFC) has been implicated in a number of psychiatric disorders, including depression, anxiety, phobia, and obsessive-compulsive disorder. Thus, a better understanding of its functions will likely provide critical information to understand the specific behavioral and cognitive processes affected in these human disorders. In recent years, a growing number of studies have provided evidence for anatomical and functional differentiation within the OFC. Here we discuss the effects of selective OFC (areas 11/13) lesions on social behavior, emotional regulation, and behavioral adaptation. Damage to these specific OFC subfields in adult monkeys resulted in profound changes in the flexible modulation of responses guided by reward value that could explain the poor fear regulation and disturbed social interactions observed in the same animals. A similar pattern of results was found when the OFC lesions were done in infancy. Thus, in monkeys, self-regulation abilities mediated by OFC areas 11/13 emerge from midinfancy through adolescence.
KW - Behavior
KW - Emotion
KW - Flexibility
KW - Orbitofrontal cortex
KW - Rhesus
UR - http://www.scopus.com/inward/record.url?scp=83155190329&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=83155190329&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2011.06211.x
DO - 10.1111/j.1749-6632.2011.06211.x
M3 - Article
C2 - 22145877
AN - SCOPUS:83155190329
VL - 1239
SP - 71
EP - 86
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
SN - 0077-8923
IS - 1
ER -