Abstract
After an 11 day base line of behavioral observations, 24 chronic female schizophrenics were assigned to 2 groups matched for alertness. In the first treatment phase, the administration of phenothiazine medication of 1 group was switched from a multiple dose schedule (3 to 4 times per day) to a single daily administration, while the total dosage per day was held constant. The second group continued on a multiple administration schedule for 11 days and then was switched to a single daily dosage. A multivariate analysis of variance showed that there was no overall effect (positive or negative) due to the schedule change; however, preplanned t tests showed transitory decreases in nonfunctional behavior. The results are discussed in terms of implications for the administration of phenothiazines and the experimental analysis of drug effects.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1285-1290 |
| Number of pages | 6 |
| Journal | Archives of General Psychiatry |
| Volume | 32 |
| Issue number | 10 |
| State | Published - 1975 |
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ASJC Scopus subject areas
- Psychiatry and Mental health
Cite this
Behavioral effects of reducing the daily frequency of phenothiazine administration. / Callahan, Edward J; Alevizos, P. N.; Teigen, J. R.; Newman, H.; Campbell, M. D.
In: Archives of General Psychiatry, Vol. 32, No. 10, 1975, p. 1285-1290.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Behavioral effects of reducing the daily frequency of phenothiazine administration
AU - Callahan, Edward J
AU - Alevizos, P. N.
AU - Teigen, J. R.
AU - Newman, H.
AU - Campbell, M. D.
PY - 1975
Y1 - 1975
N2 - After an 11 day base line of behavioral observations, 24 chronic female schizophrenics were assigned to 2 groups matched for alertness. In the first treatment phase, the administration of phenothiazine medication of 1 group was switched from a multiple dose schedule (3 to 4 times per day) to a single daily administration, while the total dosage per day was held constant. The second group continued on a multiple administration schedule for 11 days and then was switched to a single daily dosage. A multivariate analysis of variance showed that there was no overall effect (positive or negative) due to the schedule change; however, preplanned t tests showed transitory decreases in nonfunctional behavior. The results are discussed in terms of implications for the administration of phenothiazines and the experimental analysis of drug effects.
AB - After an 11 day base line of behavioral observations, 24 chronic female schizophrenics were assigned to 2 groups matched for alertness. In the first treatment phase, the administration of phenothiazine medication of 1 group was switched from a multiple dose schedule (3 to 4 times per day) to a single daily administration, while the total dosage per day was held constant. The second group continued on a multiple administration schedule for 11 days and then was switched to a single daily dosage. A multivariate analysis of variance showed that there was no overall effect (positive or negative) due to the schedule change; however, preplanned t tests showed transitory decreases in nonfunctional behavior. The results are discussed in terms of implications for the administration of phenothiazines and the experimental analysis of drug effects.
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M3 - Article
C2 - 241307
AN - SCOPUS:0016780553
VL - 32
SP - 1285
EP - 1290
JO - JAMA Psychiatry
JF - JAMA Psychiatry
SN - 2168-622X
IS - 10
ER -