Behavioral effects of reducing the daily frequency of phenothiazine administration

Edward J Callahan, P. N. Alevizos, J. R. Teigen, H. Newman, M. D. Campbell

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


After an 11 day base line of behavioral observations, 24 chronic female schizophrenics were assigned to 2 groups matched for alertness. In the first treatment phase, the administration of phenothiazine medication of 1 group was switched from a multiple dose schedule (3 to 4 times per day) to a single daily administration, while the total dosage per day was held constant. The second group continued on a multiple administration schedule for 11 days and then was switched to a single daily dosage. A multivariate analysis of variance showed that there was no overall effect (positive or negative) due to the schedule change; however, preplanned t tests showed transitory decreases in nonfunctional behavior. The results are discussed in terms of implications for the administration of phenothiazines and the experimental analysis of drug effects.

Original languageEnglish (US)
Pages (from-to)1285-1290
Number of pages6
JournalArchives of General Psychiatry
Issue number10
StatePublished - 1975

ASJC Scopus subject areas

  • Psychiatry and Mental health


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