Behavioral effects of prenatal ketamine exposure in rhesus macaques are dependent on MAOA genotype

John P. Capitanio, Laura A. Del Rosso, Laura A. Calonder, Shelley A. Blozis, Cecilia Penedo

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Ketamine is an N-methyl-D-aspartate (NMDA) receptor antagonist that is used in anesthetic, abuse, and therapeutic contexts. Recent evidence suggests that ketamine may affect not only glutamate systems, but may also act on receptors in the dopamine and serotonin systems. Because monoamine neurotransmitters play important trophic roles in prenatal development, we hypothesized that the behavioral consequences of prenatal exposure to ketamine may be moderated by genotype of the promoter in the monoamine oxidase-A (MAOA) gene. Eighty-two infant rhesus monkeys were identified that had known dates of conception and exposures to ketamine during gestation. Animals were tested at 3-4 months of age on a battery of tests assessing responsiveness to maternal separation, recognition memory, and contact with novel objects. Animals were classified by putative activity levels for the MAOA genotype. The effects of prenatal ketamine exposure were seen only in the context of MAOA genotype. Greater exposure to ketamine resulted in increased activity, less willingness to perform in the memory task, and reduced emotionality and novel-object contact, but only for individuals with the low-activity genotype. Nearly all effects of ketamine were the result of first-and second-trimester exposure. MAOA genotype moderates the role of prenatal ketamine exposure at time points in gestation earlier than have been shown in past research, and is particularly evident for measures of emotionality. These results support the idea that ketamine's use might be best considered in light of individuals' genetic characteristics.

Original languageEnglish (US)
Pages (from-to)173-180
Number of pages8
JournalExperimental and Clinical Psychopharmacology
Volume20
Issue number3
DOIs
StatePublished - Jun 1 2012

Fingerprint

Monoamine Oxidase
Ketamine
Macaca mulatta
Genotype
Pregnancy
Serotonin Receptors
Dopamine Receptors
Second Pregnancy Trimester
First Pregnancy Trimester
N-Methyl-D-Aspartate Receptors
Neurotransmitter Agents
Anesthetics
Glutamic Acid
Mothers

Keywords

  • Anxiety
  • Ketamine
  • MAOA
  • Rhesus monkey
  • Temperament

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Behavioral effects of prenatal ketamine exposure in rhesus macaques are dependent on MAOA genotype. / Capitanio, John P.; Del Rosso, Laura A.; Calonder, Laura A.; Blozis, Shelley A.; Penedo, Cecilia.

In: Experimental and Clinical Psychopharmacology, Vol. 20, No. 3, 01.06.2012, p. 173-180.

Research output: Contribution to journalArticle

Capitanio, John P. ; Del Rosso, Laura A. ; Calonder, Laura A. ; Blozis, Shelley A. ; Penedo, Cecilia. / Behavioral effects of prenatal ketamine exposure in rhesus macaques are dependent on MAOA genotype. In: Experimental and Clinical Psychopharmacology. 2012 ; Vol. 20, No. 3. pp. 173-180.
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