BEHAVIORAL EFFECTS OF METHYL PARATHION AND TOXAPHENE EXPOSURE IN RATS.

L. A. Crowder, Gregory C Lanzaro, R. S. Whitson

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The behavior of rats exposed peri- and postnatally to methyl parathion (MP) and toxaphene (T) was examined with a variety of maturational and learning tests. Females received daily oral doses of 1. 0 mg/kg MP or 1. 0 mg/kg MP plus 2. 0 mg/kg T between Days 7-15 of pregnancy. With T alone, rats of the postnatal group were dosed daily with 6 mg/kg for 21 days, while in the perinatal study females received 6 mg/kg daily from Day 7 of pregnancy until parturition. Rat pups exposed to sublethal doses of MP and T in combination or alone demonstrated few significant changes in learning ability as measured by a simple two-choice maze, motor skills, or behavior.

Original languageEnglish (US)
Pages (from-to)365-378
Number of pages14
JournalJournal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes
VolumeB15
Issue number4
StatePublished - 1980
Externally publishedYes

Fingerprint

Toxaphene
Methyl Parathion
toxaphene
parathion-methyl
pregnancy
Rats
learning
parturition
rats
Learning
Pregnancy
Motor Skills
Aptitude
dosage
pups
mouth
Parturition
dose
exposure
effect

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Waste Management and Disposal
  • Public Health, Environmental and Occupational Health

Cite this

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abstract = "The behavior of rats exposed peri- and postnatally to methyl parathion (MP) and toxaphene (T) was examined with a variety of maturational and learning tests. Females received daily oral doses of 1. 0 mg/kg MP or 1. 0 mg/kg MP plus 2. 0 mg/kg T between Days 7-15 of pregnancy. With T alone, rats of the postnatal group were dosed daily with 6 mg/kg for 21 days, while in the perinatal study females received 6 mg/kg daily from Day 7 of pregnancy until parturition. Rat pups exposed to sublethal doses of MP and T in combination or alone demonstrated few significant changes in learning ability as measured by a simple two-choice maze, motor skills, or behavior.",
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AB - The behavior of rats exposed peri- and postnatally to methyl parathion (MP) and toxaphene (T) was examined with a variety of maturational and learning tests. Females received daily oral doses of 1. 0 mg/kg MP or 1. 0 mg/kg MP plus 2. 0 mg/kg T between Days 7-15 of pregnancy. With T alone, rats of the postnatal group were dosed daily with 6 mg/kg for 21 days, while in the perinatal study females received 6 mg/kg daily from Day 7 of pregnancy until parturition. Rat pups exposed to sublethal doses of MP and T in combination or alone demonstrated few significant changes in learning ability as measured by a simple two-choice maze, motor skills, or behavior.

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