TY - JOUR
T1 - Behavioral correlates of maternal antibody status among children with autism
AU - Braunschweig, Daniel
AU - Duncanson, Paul
AU - Boyce, Robert
AU - Hansen, Robin L
AU - Ashwood, Paul
AU - Pessah, Isaac N
AU - Hertz-Picciotto, Irva
AU - Van de Water, Judith A
PY - 2012/7
Y1 - 2012/7
N2 - Autism spectrum disorders (ASDs) affect approximately 1 in 110 children in the United States. This report profiles fetal-brain reactive autoantibodies of a large cohort of mothers of children with autism and controls, yielding significant associations between the presence of IgG reactivity to fetal brain proteins at 37 and 73 kDa and a childhood diagnosis of full autism (p = 0.0005), which also correlated with lower expressive language scores (p = 0.005). Additionally, we report on reactivity to proteins at 39 and 73 kDa, which correlated with the broader diagnosis of ASD (p = 0.0007) and increased irritability on the Aberrant Behavioral Checklist (p = 0.05). This study provides evidence of multiple patterns of reactivity to fetal brain proteins by maternal antibodies associated with ASD and specific childhood behavioral outcomes.
AB - Autism spectrum disorders (ASDs) affect approximately 1 in 110 children in the United States. This report profiles fetal-brain reactive autoantibodies of a large cohort of mothers of children with autism and controls, yielding significant associations between the presence of IgG reactivity to fetal brain proteins at 37 and 73 kDa and a childhood diagnosis of full autism (p = 0.0005), which also correlated with lower expressive language scores (p = 0.005). Additionally, we report on reactivity to proteins at 39 and 73 kDa, which correlated with the broader diagnosis of ASD (p = 0.0007) and increased irritability on the Aberrant Behavioral Checklist (p = 0.05). This study provides evidence of multiple patterns of reactivity to fetal brain proteins by maternal antibodies associated with ASD and specific childhood behavioral outcomes.
KW - Autism
KW - Autoantibodies
KW - Fetal brain
KW - Maternal antibodies
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U2 - 10.1007/s10803-011-1378-7
DO - 10.1007/s10803-011-1378-7
M3 - Article
C2 - 22012245
AN - SCOPUS:84863878407
VL - 42
SP - 1435
EP - 1445
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
SN - 0162-3257
IS - 7
ER -