Behavioral correlates of maternal antibody status among children with autism

Daniel Braunschweig, Paul Duncanson, Robert Boyce, Robin L Hansen, Paul Ashwood, Isaac N Pessah, Irva Hertz-Picciotto, Judith A Van de Water

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

Autism spectrum disorders (ASDs) affect approximately 1 in 110 children in the United States. This report profiles fetal-brain reactive autoantibodies of a large cohort of mothers of children with autism and controls, yielding significant associations between the presence of IgG reactivity to fetal brain proteins at 37 and 73 kDa and a childhood diagnosis of full autism (p = 0.0005), which also correlated with lower expressive language scores (p = 0.005). Additionally, we report on reactivity to proteins at 39 and 73 kDa, which correlated with the broader diagnosis of ASD (p = 0.0007) and increased irritability on the Aberrant Behavioral Checklist (p = 0.05). This study provides evidence of multiple patterns of reactivity to fetal brain proteins by maternal antibodies associated with ASD and specific childhood behavioral outcomes.

Original languageEnglish (US)
Pages (from-to)1435-1445
Number of pages11
JournalJournal of Autism and Developmental Disorders
Volume42
Issue number7
DOIs
StatePublished - Jul 2012

Keywords

  • Autism
  • Autoantibodies
  • Fetal brain
  • Maternal antibodies

ASJC Scopus subject areas

  • Developmental and Educational Psychology

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