Behavioral characterization of two long-lasting adenosine analogs: Sedative properties and interaction with diazepam

Jacqueline Crawley, Jitendra Patel, Paul J. Marangos

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Abstract

Behavioral analysis of the sedative properties of two potent long-lasting adenosine analogs was performed in mice, using a video-tracking computer-assisted animal behavior monitor. Cyclohexyladenosine (CHA) and 2-chloroadenosine significantly decreased number of movements, increased duration of pauses, and decreased the mean exploratory distance per move, beginning at 0.5 mg/kg i.p. Rotorod analysis of motor coordination and hotplate testing for analgesia also showed significant deficits at these low doses. Diazepam-induced increases in exploratory behavior were reversed by adenosine and its analogs, supporting the possibility of benzodiazepine-adenosine interactions in the central nervous system.

Original languageEnglish (US)
Pages (from-to)2623-2630
Number of pages8
JournalLife Sciences
Volume29
Issue number25
DOIs
StatePublished - Dec 21 1981
Externally publishedYes

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ASJC Scopus subject areas

  • Pharmacology

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