Abstract
Behavioral analysis of the sedative properties of two potent long-lasting adenosine analogs was performed in mice, using a video-tracking computer-assisted animal behavior monitor. Cyclohexyladenosine (CHA) and 2-chloroadenosine significantly decreased number of movements, increased duration of pauses, and decreased the mean exploratory distance per move, beginning at 0.5 mg/kg i.p. Rotorod analysis of motor coordination and hotplate testing for analgesia also showed significant deficits at these low doses. Diazepam-induced increases in exploratory behavior were reversed by adenosine and its analogs, supporting the possibility of benzodiazepine-adenosine interactions in the central nervous system.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2623-2630 |
| Number of pages | 8 |
| Journal | Life Sciences |
| Volume | 29 |
| Issue number | 25 |
| DOIs | |
| State | Published - Dec 21 1981 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology
Cite this
Behavioral characterization of two long-lasting adenosine analogs : Sedative properties and interaction with diazepam. / Crawley, Jacqueline; Patel, Jitendra; Marangos, Paul J.
In: Life Sciences, Vol. 29, No. 25, 21.12.1981, p. 2623-2630.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Behavioral characterization of two long-lasting adenosine analogs
T2 - Sedative properties and interaction with diazepam
AU - Crawley, Jacqueline
AU - Patel, Jitendra
AU - Marangos, Paul J.
PY - 1981/12/21
Y1 - 1981/12/21
N2 - Behavioral analysis of the sedative properties of two potent long-lasting adenosine analogs was performed in mice, using a video-tracking computer-assisted animal behavior monitor. Cyclohexyladenosine (CHA) and 2-chloroadenosine significantly decreased number of movements, increased duration of pauses, and decreased the mean exploratory distance per move, beginning at 0.5 mg/kg i.p. Rotorod analysis of motor coordination and hotplate testing for analgesia also showed significant deficits at these low doses. Diazepam-induced increases in exploratory behavior were reversed by adenosine and its analogs, supporting the possibility of benzodiazepine-adenosine interactions in the central nervous system.
AB - Behavioral analysis of the sedative properties of two potent long-lasting adenosine analogs was performed in mice, using a video-tracking computer-assisted animal behavior monitor. Cyclohexyladenosine (CHA) and 2-chloroadenosine significantly decreased number of movements, increased duration of pauses, and decreased the mean exploratory distance per move, beginning at 0.5 mg/kg i.p. Rotorod analysis of motor coordination and hotplate testing for analgesia also showed significant deficits at these low doses. Diazepam-induced increases in exploratory behavior were reversed by adenosine and its analogs, supporting the possibility of benzodiazepine-adenosine interactions in the central nervous system.
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U2 - 10.1016/0024-3205(81)90636-6
DO - 10.1016/0024-3205(81)90636-6
M3 - Article
VL - 29
SP - 2623
EP - 2630
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 25
ER -