Behavioral characterization of two long-lasting adenosine analogs

Sedative properties and interaction with diazepam

Jacqueline Crawley, Jitendra Patel, Paul J. Marangos

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Behavioral analysis of the sedative properties of two potent long-lasting adenosine analogs was performed in mice, using a video-tracking computer-assisted animal behavior monitor. Cyclohexyladenosine (CHA) and 2-chloroadenosine significantly decreased number of movements, increased duration of pauses, and decreased the mean exploratory distance per move, beginning at 0.5 mg/kg i.p. Rotorod analysis of motor coordination and hotplate testing for analgesia also showed significant deficits at these low doses. Diazepam-induced increases in exploratory behavior were reversed by adenosine and its analogs, supporting the possibility of benzodiazepine-adenosine interactions in the central nervous system.

Original languageEnglish (US)
Pages (from-to)2623-2630
Number of pages8
JournalLife Sciences
Volume29
Issue number25
DOIs
StatePublished - Dec 21 1981
Externally publishedYes

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Diazepam
Hypnotics and Sedatives
Adenosine
2-Chloroadenosine
Animal Behavior
Exploratory Behavior
Neurology
Benzodiazepines
Analgesia
Animals
Central Nervous System
Testing

ASJC Scopus subject areas

  • Pharmacology

Cite this

Behavioral characterization of two long-lasting adenosine analogs : Sedative properties and interaction with diazepam. / Crawley, Jacqueline; Patel, Jitendra; Marangos, Paul J.

In: Life Sciences, Vol. 29, No. 25, 21.12.1981, p. 2623-2630.

Research output: Contribution to journalArticle

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