Abstract
Behavioral analysis of the sedative properties of two potent long-lasting adenosine analogs was performed in mice, using a video-tracking computer-assisted animal behavior monitor. Cyclohexyladenosine (CHA) and 2-chloroadenosine significantly decreased number of movements, increased duration of pauses, and decreased the mean exploratory distance per move, beginning at 0.5 mg/kg i.p. Rotorod analysis of motor coordination and hotplate testing for analgesia also showed significant deficits at these low doses. Diazepam-induced increases in exploratory behavior were reversed by adenosine and its analogs, supporting the possibility of benzodiazepine-adenosine interactions in the central nervous system.
Original language | English (US) |
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Pages (from-to) | 2623-2630 |
Number of pages | 8 |
Journal | Life Sciences |
Volume | 29 |
Issue number | 25 |
DOIs | |
State | Published - Dec 21 1981 |
Externally published | Yes |
ASJC Scopus subject areas
- Pharmacology