Behavioral characterization of dopamine D5 receptor null mutant mice

A. Holmes, T. R. Hollon, T. C. Gleason, Z. Liu, J. Dreiling, D. R. Sibley, Jacqueline Crawley

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

To study behavioral functions of the D5 subtype, mice were generated with null mutations in the D5 gene. This 1st behavioral characterization of D5 null mutant mice (D5 -/-) indicated normal general health, sensory abilities, and neurological reflexes. Under basal conditions, D5 -/- mice were generally normal on locomotor activity, the rotarod test, acoustic startle response, prepulse inhibition, elevated plus-maze, light ↔ dark exploration, Morris water maze, and cued and contextual fear conditioning. In the Porsolt forced swim test for antidepressant activity, male D5 -/- mice showed lower levels of immobility. D5 -/- mice showed some evidence of reduced responses to the hyperactivity-inducing effects of the D1/D5 receptor agonist SKF 81297. The ability of SKF 81297 to disrupt acoustic startle and prepulse inhibition appeared to be attenuated in D5 -/- mice. These results suggest that the D5 receptor is not essential for many dopamine-mediated behaviors but may contribute to the pharmacological activation of dopaminergic pathways relevant to exploratory locomotion, startle, and prepulse inhibition.

Original languageEnglish (US)
Pages (from-to)1129-1144
Number of pages16
JournalBehavioral Neuroscience
Volume115
Issue number5
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Dopamine D5 Receptors
Aptitude
Locomotion
Acoustics
Startle Reflex
Rotarod Performance Test
Antidepressive Agents
Fear
Reflex
Dopamine
Pharmacology
Light
Mutation
Water
Health

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Clinical Psychology

Cite this

Holmes, A., Hollon, T. R., Gleason, T. C., Liu, Z., Dreiling, J., Sibley, D. R., & Crawley, J. (2001). Behavioral characterization of dopamine D5 receptor null mutant mice. Behavioral Neuroscience, 115(5), 1129-1144. https://doi.org/10.1037/0735-7044.115.5.1129

Behavioral characterization of dopamine D5 receptor null mutant mice. / Holmes, A.; Hollon, T. R.; Gleason, T. C.; Liu, Z.; Dreiling, J.; Sibley, D. R.; Crawley, Jacqueline.

In: Behavioral Neuroscience, Vol. 115, No. 5, 2001, p. 1129-1144.

Research output: Contribution to journalArticle

Holmes, A, Hollon, TR, Gleason, TC, Liu, Z, Dreiling, J, Sibley, DR & Crawley, J 2001, 'Behavioral characterization of dopamine D5 receptor null mutant mice', Behavioral Neuroscience, vol. 115, no. 5, pp. 1129-1144. https://doi.org/10.1037/0735-7044.115.5.1129
Holmes A, Hollon TR, Gleason TC, Liu Z, Dreiling J, Sibley DR et al. Behavioral characterization of dopamine D5 receptor null mutant mice. Behavioral Neuroscience. 2001;115(5):1129-1144. https://doi.org/10.1037/0735-7044.115.5.1129
Holmes, A. ; Hollon, T. R. ; Gleason, T. C. ; Liu, Z. ; Dreiling, J. ; Sibley, D. R. ; Crawley, Jacqueline. / Behavioral characterization of dopamine D5 receptor null mutant mice. In: Behavioral Neuroscience. 2001 ; Vol. 115, No. 5. pp. 1129-1144.
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