Abstract
To study behavioral functions of the D5 subtype, mice were generated with null mutations in the D5 gene. This 1st behavioral characterization of D5 null mutant mice (D5 -/-) indicated normal general health, sensory abilities, and neurological reflexes. Under basal conditions, D5 -/- mice were generally normal on locomotor activity, the rotarod test, acoustic startle response, prepulse inhibition, elevated plus-maze, light ↔ dark exploration, Morris water maze, and cued and contextual fear conditioning. In the Porsolt forced swim test for antidepressant activity, male D5 -/- mice showed lower levels of immobility. D5 -/- mice showed some evidence of reduced responses to the hyperactivity-inducing effects of the D1/D5 receptor agonist SKF 81297. The ability of SKF 81297 to disrupt acoustic startle and prepulse inhibition appeared to be attenuated in D5 -/- mice. These results suggest that the D5 receptor is not essential for many dopamine-mediated behaviors but may contribute to the pharmacological activation of dopaminergic pathways relevant to exploratory locomotion, startle, and prepulse inhibition.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1129-1144 |
| Number of pages | 16 |
| Journal | Behavioral Neuroscience |
| Volume | 115 |
| Issue number | 5 |
| DOIs | |
| State | Published - 2001 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Behavioral Neuroscience
- Clinical Psychology
Cite this
Behavioral characterization of dopamine D5 receptor null mutant mice. / Holmes, A.; Hollon, T. R.; Gleason, T. C.; Liu, Z.; Dreiling, J.; Sibley, D. R.; Crawley, Jacqueline.
In: Behavioral Neuroscience, Vol. 115, No. 5, 2001, p. 1129-1144.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Behavioral characterization of dopamine D5 receptor null mutant mice
AU - Holmes, A.
AU - Hollon, T. R.
AU - Gleason, T. C.
AU - Liu, Z.
AU - Dreiling, J.
AU - Sibley, D. R.
AU - Crawley, Jacqueline
PY - 2001
Y1 - 2001
N2 - To study behavioral functions of the D5 subtype, mice were generated with null mutations in the D5 gene. This 1st behavioral characterization of D5 null mutant mice (D5 -/-) indicated normal general health, sensory abilities, and neurological reflexes. Under basal conditions, D5 -/- mice were generally normal on locomotor activity, the rotarod test, acoustic startle response, prepulse inhibition, elevated plus-maze, light ↔ dark exploration, Morris water maze, and cued and contextual fear conditioning. In the Porsolt forced swim test for antidepressant activity, male D5 -/- mice showed lower levels of immobility. D5 -/- mice showed some evidence of reduced responses to the hyperactivity-inducing effects of the D1/D5 receptor agonist SKF 81297. The ability of SKF 81297 to disrupt acoustic startle and prepulse inhibition appeared to be attenuated in D5 -/- mice. These results suggest that the D5 receptor is not essential for many dopamine-mediated behaviors but may contribute to the pharmacological activation of dopaminergic pathways relevant to exploratory locomotion, startle, and prepulse inhibition.
AB - To study behavioral functions of the D5 subtype, mice were generated with null mutations in the D5 gene. This 1st behavioral characterization of D5 null mutant mice (D5 -/-) indicated normal general health, sensory abilities, and neurological reflexes. Under basal conditions, D5 -/- mice were generally normal on locomotor activity, the rotarod test, acoustic startle response, prepulse inhibition, elevated plus-maze, light ↔ dark exploration, Morris water maze, and cued and contextual fear conditioning. In the Porsolt forced swim test for antidepressant activity, male D5 -/- mice showed lower levels of immobility. D5 -/- mice showed some evidence of reduced responses to the hyperactivity-inducing effects of the D1/D5 receptor agonist SKF 81297. The ability of SKF 81297 to disrupt acoustic startle and prepulse inhibition appeared to be attenuated in D5 -/- mice. These results suggest that the D5 receptor is not essential for many dopamine-mediated behaviors but may contribute to the pharmacological activation of dopaminergic pathways relevant to exploratory locomotion, startle, and prepulse inhibition.
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U2 - 10.1037/0735-7044.115.5.1129
DO - 10.1037/0735-7044.115.5.1129
M3 - Article
VL - 115
SP - 1129
EP - 1144
JO - Behavioral Neuroscience
JF - Behavioral Neuroscience
SN - 0735-7044
IS - 5
ER -