Abstract
ErbB4 is an important brain receptor for the neuregulin1 growth factor. A conditional knock-out mouse was developed lacking both alleles of the erbB4 gene in neurons/glia, and one allele in other cells. The conditional mutant mice were compared to heterozygous null (one null allele and one wildtype allele in all tissues) and wildtype control (no gene deletion) littermates in a battery of behavioral tests. Conditional mutants displayed a lower level of spontaneous motor activity and reduced grip strength compared to wildtype control mice. Group mean scores of heterozygous nulls were intermediate on these measures. However, heterozygous nulls were delayed in motor development and male heterozygous nulls demonstrated altered cue use in a Morris maze learning and memory task relative to both wildtype control and conditional mutant mice. These findings were interpreted based on more detailed analysis of the behavioral data and considerations of the complex nature and multiple roles of the neuregulin/erbB4 system in the nervous system.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 159-170 |
| Number of pages | 12 |
| Journal | Behavioural Brain Research |
| Volume | 153 |
| Issue number | 1 |
| DOIs | |
| State | Published - Aug 12 2004 |
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Keywords
- Cerebellum
- Conditional knock-out
- EGF
- erbB4
- Morris maze
- Motor activity
- Mouse
- Neuregulin
- Postnatal development
ASJC Scopus subject areas
- Behavioral Neuroscience
Cite this
Behavioral characteristics of a nervous system-specific erbB4 knock-out mouse. / Golub, Mari S.; Germann, Stacey L.; Lloyd, Kevin C K.
In: Behavioural Brain Research, Vol. 153, No. 1, 12.08.2004, p. 159-170.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Behavioral characteristics of a nervous system-specific erbB4 knock-out mouse
AU - Golub, Mari S.
AU - Germann, Stacey L.
AU - Lloyd, Kevin C K
PY - 2004/8/12
Y1 - 2004/8/12
N2 - ErbB4 is an important brain receptor for the neuregulin1 growth factor. A conditional knock-out mouse was developed lacking both alleles of the erbB4 gene in neurons/glia, and one allele in other cells. The conditional mutant mice were compared to heterozygous null (one null allele and one wildtype allele in all tissues) and wildtype control (no gene deletion) littermates in a battery of behavioral tests. Conditional mutants displayed a lower level of spontaneous motor activity and reduced grip strength compared to wildtype control mice. Group mean scores of heterozygous nulls were intermediate on these measures. However, heterozygous nulls were delayed in motor development and male heterozygous nulls demonstrated altered cue use in a Morris maze learning and memory task relative to both wildtype control and conditional mutant mice. These findings were interpreted based on more detailed analysis of the behavioral data and considerations of the complex nature and multiple roles of the neuregulin/erbB4 system in the nervous system.
AB - ErbB4 is an important brain receptor for the neuregulin1 growth factor. A conditional knock-out mouse was developed lacking both alleles of the erbB4 gene in neurons/glia, and one allele in other cells. The conditional mutant mice were compared to heterozygous null (one null allele and one wildtype allele in all tissues) and wildtype control (no gene deletion) littermates in a battery of behavioral tests. Conditional mutants displayed a lower level of spontaneous motor activity and reduced grip strength compared to wildtype control mice. Group mean scores of heterozygous nulls were intermediate on these measures. However, heterozygous nulls were delayed in motor development and male heterozygous nulls demonstrated altered cue use in a Morris maze learning and memory task relative to both wildtype control and conditional mutant mice. These findings were interpreted based on more detailed analysis of the behavioral data and considerations of the complex nature and multiple roles of the neuregulin/erbB4 system in the nervous system.
KW - Cerebellum
KW - Conditional knock-out
KW - EGF
KW - erbB4
KW - Morris maze
KW - Motor activity
KW - Mouse
KW - Neuregulin
KW - Postnatal development
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UR - http://www.scopus.com/inward/citedby.url?scp=3042640878&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2003.11.010
DO - 10.1016/j.bbr.2003.11.010
M3 - Article
C2 - 15219717
AN - SCOPUS:3042640878
VL - 153
SP - 159
EP - 170
JO - Behavioural Brain Research
JF - Behavioural Brain Research
SN - 0166-4328
IS - 1
ER -