Behavioral and neurochemical changes in folate-deficient mice

Sidney M. Gospe, Dorothy W. Gietzen, Philip J. Summers, Jennine M. Lunetta, Joshua W. Miller, Jacob Selhub, William G. Ellis, Andrew J. Clifford

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Weanling mice were fed an amino acid-based diet supplemented with 0 or 11.3 μmol folic acid/kg diet for ∼ 38 days to study behavior and neurochemistry in folate deficiency. After ∼ 5 wk, mice fed the unsupplemented diet weighed ∼ 70% as much those fed the supplemented diet. After 2 wk, mice fed the unsupplemented diet consistently discarded (spilled) more food, and after ∼ 5 wk, they had spilled 3 times more than mice fed the supplemented diet. Serum folate, brain folate and brain S-adenosylmethionine of mice fed the unsupplemented diet were 4, 53, and 60% as high, respectively, as those of mice fed the supplemented diet. Pathologic changes were not evident in brain, spinal cord, or skeletal muscle of folate-deficient mice. The hypothalamic 5-hydroxyindole acetic acid/serotonin ratio and caudate dopamine, homovanillic acid, and 3,4-dihydroxyphenylacetic acid concentrations were lower in deficient than control mice. Folate-deficient mice develop a behavioral activity, food spilling, which may have a neurochemical basis in the serotonin and dopamine systems.

Original languageEnglish (US)
Pages (from-to)935-941
Number of pages7
JournalPhysiology and Behavior
Volume58
Issue number5
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Folic Acid
Diet
Dopamine
Serotonin
Brain
Neurochemistry
3,4-Dihydroxyphenylacetic Acid
Food
S-Adenosylmethionine
Homovanillic Acid
Acetic Acid
Spinal Cord
Skeletal Muscle
Amino Acids
Serum

Keywords

  • Dopamine
  • Folate deficiency
  • Food spilling behavior
  • Mice
  • Serotonin

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Experimental and Cognitive Psychology
  • Physiology (medical)

Cite this

Gospe, S. M., Gietzen, D. W., Summers, P. J., Lunetta, J. M., Miller, J. W., Selhub, J., ... Clifford, A. J. (1995). Behavioral and neurochemical changes in folate-deficient mice. Physiology and Behavior, 58(5), 935-941. https://doi.org/10.1016/0031-9384(95)00156-D

Behavioral and neurochemical changes in folate-deficient mice. / Gospe, Sidney M.; Gietzen, Dorothy W.; Summers, Philip J.; Lunetta, Jennine M.; Miller, Joshua W.; Selhub, Jacob; Ellis, William G.; Clifford, Andrew J.

In: Physiology and Behavior, Vol. 58, No. 5, 1995, p. 935-941.

Research output: Contribution to journalArticle

Gospe, SM, Gietzen, DW, Summers, PJ, Lunetta, JM, Miller, JW, Selhub, J, Ellis, WG & Clifford, AJ 1995, 'Behavioral and neurochemical changes in folate-deficient mice', Physiology and Behavior, vol. 58, no. 5, pp. 935-941. https://doi.org/10.1016/0031-9384(95)00156-D
Gospe SM, Gietzen DW, Summers PJ, Lunetta JM, Miller JW, Selhub J et al. Behavioral and neurochemical changes in folate-deficient mice. Physiology and Behavior. 1995;58(5):935-941. https://doi.org/10.1016/0031-9384(95)00156-D
Gospe, Sidney M. ; Gietzen, Dorothy W. ; Summers, Philip J. ; Lunetta, Jennine M. ; Miller, Joshua W. ; Selhub, Jacob ; Ellis, William G. ; Clifford, Andrew J. / Behavioral and neurochemical changes in folate-deficient mice. In: Physiology and Behavior. 1995 ; Vol. 58, No. 5. pp. 935-941.
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