Behavioral and Neuroanatomical Phenotypes in Mouse Models of Autism

Jacob Ellegood, Jacqueline Crawley

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

In order to understand the consequences of the mutation on behavioral and biological phenotypes relevant to autism, mutations in many of the risk genes for autism spectrum disorder have been experimentally generated in mice. Here, we summarize behavioral outcomes and neuroanatomical abnormalities, with a focus on high-resolution magnetic resonance imaging of postmortem mouse brains. Results are described from multiple mouse models of autism spectrum disorder and comorbid syndromes, including the 15q11-13, 16p11.2, 22q11.2, Cntnap2, Engrailed2, Fragile X, Integrinβ3, MET, Neurexin1a, Neuroligin3, Reelin, Rett, Shank3, Slc6a4, tuberous sclerosis, and Williams syndrome models, and inbred strains with strong autism-relevant behavioral phenotypes, including BTBR and BALB. Concomitant behavioral and neuroanatomical abnormalities can strengthen the interpretation of results from a mouse model, and may elevate the usefulness of the model system for therapeutic discovery.

Original languageEnglish (US)
Pages (from-to)521-533
Number of pages13
JournalNeurotherapeutics
Volume12
Issue number3
DOIs
StatePublished - Jun 3 2015

Keywords

  • Autism
  • Behaviour
  • Magnetic resonance imaging (MRI)
  • Neuroanatomy

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Clinical Neurology
  • Pharmacology

Fingerprint Dive into the research topics of 'Behavioral and Neuroanatomical Phenotypes in Mouse Models of Autism'. Together they form a unique fingerprint.

  • Cite this