TY - JOUR
T1 - Bed rest and other determinants of bone loss during pregnancy
AU - Promislow, Joanne H E
AU - Hertz-Picciotto, Irva
AU - Schramm, Margaret
AU - Watt-Morse, Margaret
AU - Anderson, John J B
PY - 2004/10
Y1 - 2004/10
N2 - The purpose of this study was to evaluate patterns of bone loss during pregnancy and potential influences. This was a prospective study of 181 women receiving prenatal care at Magee-Womens Hospital or its auxiliary clinics in Pittsburgh, Pennsylvania, between 1992 and 1995. Bone mineral density was measured at approximately 16 and 36 weeks' gestation. Trabecular, but not cortical, bone loss occurred during pregnancy. Mean ultra-distal bone mineral density loss was 1.9% (95% CI 1.2-2.5) during the 20-week period. Women prescribed bed rest had an adjusted mean loss of 4.6% compared with 1.5% for women not prescribed bed rest (P =. 001) and 6-fold higher odds (P =. 001) of bone loss ≥5% during the 20-week period. Nulliparity, calcium intake <2000 mg/day, low weight gain, and maternal age <21 or >30 years were more modestly associated with greater bone loss. Substantial trabecular bone loss may occur during pregnancy, particularly in women prescribed bed rest. Study of postpartum bone recovery in such women is needed.
AB - The purpose of this study was to evaluate patterns of bone loss during pregnancy and potential influences. This was a prospective study of 181 women receiving prenatal care at Magee-Womens Hospital or its auxiliary clinics in Pittsburgh, Pennsylvania, between 1992 and 1995. Bone mineral density was measured at approximately 16 and 36 weeks' gestation. Trabecular, but not cortical, bone loss occurred during pregnancy. Mean ultra-distal bone mineral density loss was 1.9% (95% CI 1.2-2.5) during the 20-week period. Women prescribed bed rest had an adjusted mean loss of 4.6% compared with 1.5% for women not prescribed bed rest (P =. 001) and 6-fold higher odds (P =. 001) of bone loss ≥5% during the 20-week period. Nulliparity, calcium intake <2000 mg/day, low weight gain, and maternal age <21 or >30 years were more modestly associated with greater bone loss. Substantial trabecular bone loss may occur during pregnancy, particularly in women prescribed bed rest. Study of postpartum bone recovery in such women is needed.
KW - Bed rest
KW - Bone loss
KW - Pregnancy
UR - http://www.scopus.com/inward/record.url?scp=7044247576&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=7044247576&partnerID=8YFLogxK
U2 - 10.1016/j.ajog.2004.05.058
DO - 10.1016/j.ajog.2004.05.058
M3 - Article
C2 - 15507924
AN - SCOPUS:7044247576
VL - 191
SP - 1077
EP - 1083
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 4
ER -