Baseline topographic optic disc measurements are associated with the development of primary open-angle glaucoma

The Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study

Linda M. Zangwill, Robert N. Weinreb, Julia A. Beiser, Charles C. Berry, George A. Cioffi, Anne L. Coleman, Gary Trick, Jeffrey M. Liebmann, James D Brandt, Jody R. Piltz-Seymour, Keri A. Dirkes, Suzanne Vega, Michael A. Kass, Mae O. Gordon

Research output: Contribution to journalArticle

132 Citations (Scopus)

Abstract

Objective: To determine whether baseline confocal scanning laser ophthalmoscopy (CSLO) optic disc topographic measurements are associated with the development of primary open-angle glaucoma (POAG) in individuals with ocular hypertension. Methods: Eight hundred sixty-five eyes from 438 participants in the CSLO Ancillary Study to the Ocular Hypertension Treatment Study with good-quality baseline CSLO images were included in this study. Each baseline CSLO parameter was assessed in univariate and multivariate proportional hazards models to determine its association with the development of POAG. Results: Forty-one eyes from 36 CSLO Ancillary Study participants developed POAG. Several baseline topographic optic disc measurements were significantly associated with the development of POAG in both univariate and multivariate analyses, including larger cup-disc area ratio, mean cup depth, mean height contour, cup volume, reference plane height, and smaller rim area, rim area to disc area, and rim volume. In addition, classification as "outside normal limits" by the Heidelberg Retina Tomograph classification and the Moorfields Regression Analysis classifications (overall, global, temporal inferior, nasal inferior, and superior temporal regions) was significantly associated with the development of POAG. Within the follow-up period of this analysis, the positive predictive value of CSLO indexes ranged from 14% (Heidelberg Retina Tomograph classification and Moorfields Regression Analysis overall classification) to 40% for Moorfields Regression Analysis temporal superior classification. Conclusions: Several baseline topographic optic disc measurements alone or when combined with baseline clinical and demographic factors were significantly associated with the development of POAG among Ocular Hypertension Treatment Study participants. Longer follow-up is required to evaluate the true predictive accuracy of CSLO measures.

Original languageEnglish (US)
Pages (from-to)1188-1197
Number of pages10
JournalArchives of Ophthalmology
Volume123
Issue number9
DOIs
StatePublished - Sep 2005

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Ophthalmoscopy
Ocular Hypertension
Optic Disk
Lasers
Regression Analysis
Retina
Demography
Temporal Lobe
Primary Open Angle Glaucoma
Nose
Proportional Hazards Models
Multivariate Analysis

ASJC Scopus subject areas

  • Ophthalmology

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Baseline topographic optic disc measurements are associated with the development of primary open-angle glaucoma : The Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study. / Zangwill, Linda M.; Weinreb, Robert N.; Beiser, Julia A.; Berry, Charles C.; Cioffi, George A.; Coleman, Anne L.; Trick, Gary; Liebmann, Jeffrey M.; Brandt, James D; Piltz-Seymour, Jody R.; Dirkes, Keri A.; Vega, Suzanne; Kass, Michael A.; Gordon, Mae O.

In: Archives of Ophthalmology, Vol. 123, No. 9, 09.2005, p. 1188-1197.

Research output: Contribution to journalArticle

Zangwill, LM, Weinreb, RN, Beiser, JA, Berry, CC, Cioffi, GA, Coleman, AL, Trick, G, Liebmann, JM, Brandt, JD, Piltz-Seymour, JR, Dirkes, KA, Vega, S, Kass, MA & Gordon, MO 2005, 'Baseline topographic optic disc measurements are associated with the development of primary open-angle glaucoma: The Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study', Archives of Ophthalmology, vol. 123, no. 9, pp. 1188-1197. https://doi.org/10.1001/archopht.123.9.1188
Zangwill, Linda M. ; Weinreb, Robert N. ; Beiser, Julia A. ; Berry, Charles C. ; Cioffi, George A. ; Coleman, Anne L. ; Trick, Gary ; Liebmann, Jeffrey M. ; Brandt, James D ; Piltz-Seymour, Jody R. ; Dirkes, Keri A. ; Vega, Suzanne ; Kass, Michael A. ; Gordon, Mae O. / Baseline topographic optic disc measurements are associated with the development of primary open-angle glaucoma : The Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study. In: Archives of Ophthalmology. 2005 ; Vol. 123, No. 9. pp. 1188-1197.
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abstract = "Objective: To determine whether baseline confocal scanning laser ophthalmoscopy (CSLO) optic disc topographic measurements are associated with the development of primary open-angle glaucoma (POAG) in individuals with ocular hypertension. Methods: Eight hundred sixty-five eyes from 438 participants in the CSLO Ancillary Study to the Ocular Hypertension Treatment Study with good-quality baseline CSLO images were included in this study. Each baseline CSLO parameter was assessed in univariate and multivariate proportional hazards models to determine its association with the development of POAG. Results: Forty-one eyes from 36 CSLO Ancillary Study participants developed POAG. Several baseline topographic optic disc measurements were significantly associated with the development of POAG in both univariate and multivariate analyses, including larger cup-disc area ratio, mean cup depth, mean height contour, cup volume, reference plane height, and smaller rim area, rim area to disc area, and rim volume. In addition, classification as {"}outside normal limits{"} by the Heidelberg Retina Tomograph classification and the Moorfields Regression Analysis classifications (overall, global, temporal inferior, nasal inferior, and superior temporal regions) was significantly associated with the development of POAG. Within the follow-up period of this analysis, the positive predictive value of CSLO indexes ranged from 14{\%} (Heidelberg Retina Tomograph classification and Moorfields Regression Analysis overall classification) to 40{\%} for Moorfields Regression Analysis temporal superior classification. Conclusions: Several baseline topographic optic disc measurements alone or when combined with baseline clinical and demographic factors were significantly associated with the development of POAG among Ocular Hypertension Treatment Study participants. Longer follow-up is required to evaluate the true predictive accuracy of CSLO measures.",
author = "Zangwill, {Linda M.} and Weinreb, {Robert N.} and Beiser, {Julia A.} and Berry, {Charles C.} and Cioffi, {George A.} and Coleman, {Anne L.} and Gary Trick and Liebmann, {Jeffrey M.} and Brandt, {James D} and Piltz-Seymour, {Jody R.} and Dirkes, {Keri A.} and Suzanne Vega and Kass, {Michael A.} and Gordon, {Mae O.}",
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T1 - Baseline topographic optic disc measurements are associated with the development of primary open-angle glaucoma

T2 - The Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study

AU - Zangwill, Linda M.

AU - Weinreb, Robert N.

AU - Beiser, Julia A.

AU - Berry, Charles C.

AU - Cioffi, George A.

AU - Coleman, Anne L.

AU - Trick, Gary

AU - Liebmann, Jeffrey M.

AU - Brandt, James D

AU - Piltz-Seymour, Jody R.

AU - Dirkes, Keri A.

AU - Vega, Suzanne

AU - Kass, Michael A.

AU - Gordon, Mae O.

PY - 2005/9

Y1 - 2005/9

N2 - Objective: To determine whether baseline confocal scanning laser ophthalmoscopy (CSLO) optic disc topographic measurements are associated with the development of primary open-angle glaucoma (POAG) in individuals with ocular hypertension. Methods: Eight hundred sixty-five eyes from 438 participants in the CSLO Ancillary Study to the Ocular Hypertension Treatment Study with good-quality baseline CSLO images were included in this study. Each baseline CSLO parameter was assessed in univariate and multivariate proportional hazards models to determine its association with the development of POAG. Results: Forty-one eyes from 36 CSLO Ancillary Study participants developed POAG. Several baseline topographic optic disc measurements were significantly associated with the development of POAG in both univariate and multivariate analyses, including larger cup-disc area ratio, mean cup depth, mean height contour, cup volume, reference plane height, and smaller rim area, rim area to disc area, and rim volume. In addition, classification as "outside normal limits" by the Heidelberg Retina Tomograph classification and the Moorfields Regression Analysis classifications (overall, global, temporal inferior, nasal inferior, and superior temporal regions) was significantly associated with the development of POAG. Within the follow-up period of this analysis, the positive predictive value of CSLO indexes ranged from 14% (Heidelberg Retina Tomograph classification and Moorfields Regression Analysis overall classification) to 40% for Moorfields Regression Analysis temporal superior classification. Conclusions: Several baseline topographic optic disc measurements alone or when combined with baseline clinical and demographic factors were significantly associated with the development of POAG among Ocular Hypertension Treatment Study participants. Longer follow-up is required to evaluate the true predictive accuracy of CSLO measures.

AB - Objective: To determine whether baseline confocal scanning laser ophthalmoscopy (CSLO) optic disc topographic measurements are associated with the development of primary open-angle glaucoma (POAG) in individuals with ocular hypertension. Methods: Eight hundred sixty-five eyes from 438 participants in the CSLO Ancillary Study to the Ocular Hypertension Treatment Study with good-quality baseline CSLO images were included in this study. Each baseline CSLO parameter was assessed in univariate and multivariate proportional hazards models to determine its association with the development of POAG. Results: Forty-one eyes from 36 CSLO Ancillary Study participants developed POAG. Several baseline topographic optic disc measurements were significantly associated with the development of POAG in both univariate and multivariate analyses, including larger cup-disc area ratio, mean cup depth, mean height contour, cup volume, reference plane height, and smaller rim area, rim area to disc area, and rim volume. In addition, classification as "outside normal limits" by the Heidelberg Retina Tomograph classification and the Moorfields Regression Analysis classifications (overall, global, temporal inferior, nasal inferior, and superior temporal regions) was significantly associated with the development of POAG. Within the follow-up period of this analysis, the positive predictive value of CSLO indexes ranged from 14% (Heidelberg Retina Tomograph classification and Moorfields Regression Analysis overall classification) to 40% for Moorfields Regression Analysis temporal superior classification. Conclusions: Several baseline topographic optic disc measurements alone or when combined with baseline clinical and demographic factors were significantly associated with the development of POAG among Ocular Hypertension Treatment Study participants. Longer follow-up is required to evaluate the true predictive accuracy of CSLO measures.

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