Baseline mean and heterogeneity of MR cartilage T 2 are associated with morphologic degeneration of cartilage, meniscus, and bone marrow over 3years - data from the Osteoarthritis Initiative

G. B. Joseph, T. Baum, H. Alizai, J. Carballido-Gamio, Lorenzo Nardo, W. Virayavanich, J. A. Lynch, M. C. Nevitt, C. E. McCulloch, S. Majumdar, T. M. Link

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Abstract

Objective: The purpose of this study is to determine whether the mean and heterogeneity of magnetic resonance (MR) knee cartilage T 2 relaxation time measurements at baseline are associated with morphologic degeneration of cartilage, meniscus, and bone marrow tissues over 3years in subjects with risk factors for osteoarthritis (OA). Design: Subjects with risk factors for OA (n=289) with an age range of 45-55years were selected from the Osteoarthritis Initiative (OAI) database. 3.0 Tesla MR images were analyzed using morphological gradings of cartilage, bone marrow and menisci whole-organ magnetic resonance imaging scores (WORMS scoring). A T 2 mapping sequence was used to assess the mean and heterogeneity of cartilage T 2 (gray level co-occurrence matrix texture analysis). Regression models were used to assess the relationship between baseline T 2 parameters and changes in morphologic knee WORMS scores over 3years. Results: The prevalence of knee abnormalities in the cartilage (P<0.0005), meniscus (P<0.00001), and bone marrow significantly (P<0.00001) increased from baseline to 3years in all compartments combined. The baseline mean and heterogeneity of cartilage T 2 were significantly (P<0.05) associated with morphologic joint degeneration in the cartilage, meniscus and bone marrow over 3years. Conclusions: The prevalence of knee abnormalities significantly increased over 3years; increased cartilage T 2 at baseline predicted longitudinal morphologic degeneration in the cartilage, meniscus, and bone marrow over 3years in subjects with risk factors for OA.

Original languageEnglish (US)
Pages (from-to)727-735
Number of pages9
JournalOsteoarthritis and Cartilage
Volume20
Issue number7
DOIs
StatePublished - Jul 1 2012
Externally publishedYes

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Keywords

  • Cartilage
  • Magnetic Resonance Imaging
  • Osteoarthritis
  • Osteoarthritis Initiative
  • T mapping

ASJC Scopus subject areas

  • Biomedical Engineering
  • Orthopedics and Sports Medicine
  • Rheumatology

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