Baseline mean and heterogeneity of MR cartilage T 2 are associated with morphologic degeneration of cartilage, meniscus, and bone marrow over 3years - data from the Osteoarthritis Initiative

G. B. Joseph, T. Baum, H. Alizai, J. Carballido-Gamio, Lorenzo Nardo, W. Virayavanich, J. A. Lynch, M. C. Nevitt, C. E. McCulloch, S. Majumdar, T. M. Link

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Objective: The purpose of this study is to determine whether the mean and heterogeneity of magnetic resonance (MR) knee cartilage T 2 relaxation time measurements at baseline are associated with morphologic degeneration of cartilage, meniscus, and bone marrow tissues over 3years in subjects with risk factors for osteoarthritis (OA). Design: Subjects with risk factors for OA (n=289) with an age range of 45-55years were selected from the Osteoarthritis Initiative (OAI) database. 3.0 Tesla MR images were analyzed using morphological gradings of cartilage, bone marrow and menisci whole-organ magnetic resonance imaging scores (WORMS scoring). A T 2 mapping sequence was used to assess the mean and heterogeneity of cartilage T 2 (gray level co-occurrence matrix texture analysis). Regression models were used to assess the relationship between baseline T 2 parameters and changes in morphologic knee WORMS scores over 3years. Results: The prevalence of knee abnormalities in the cartilage (P<0.0005), meniscus (P<0.00001), and bone marrow significantly (P<0.00001) increased from baseline to 3years in all compartments combined. The baseline mean and heterogeneity of cartilage T 2 were significantly (P<0.05) associated with morphologic joint degeneration in the cartilage, meniscus and bone marrow over 3years. Conclusions: The prevalence of knee abnormalities significantly increased over 3years; increased cartilage T 2 at baseline predicted longitudinal morphologic degeneration in the cartilage, meniscus, and bone marrow over 3years in subjects with risk factors for OA.

Original languageEnglish (US)
Pages (from-to)727-735
Number of pages9
JournalOsteoarthritis and Cartilage
Volume20
Issue number7
DOIs
StatePublished - Jul 1 2012
Externally publishedYes

Fingerprint

Cartilage
Magnetic resonance
Osteoarthritis
Bone
Magnetic Resonance Spectroscopy
Bone Marrow
Knee
Meniscus
Time measurement
Relaxation time
Textures
Joints
Magnetic Resonance Imaging
Databases
Tissue
Imaging techniques
Bone and Bones

Keywords

  • Cartilage
  • Magnetic Resonance Imaging
  • Osteoarthritis
  • Osteoarthritis Initiative
  • T mapping

ASJC Scopus subject areas

  • Biomedical Engineering
  • Orthopedics and Sports Medicine
  • Rheumatology

Cite this

Baseline mean and heterogeneity of MR cartilage T 2 are associated with morphologic degeneration of cartilage, meniscus, and bone marrow over 3years - data from the Osteoarthritis Initiative. / Joseph, G. B.; Baum, T.; Alizai, H.; Carballido-Gamio, J.; Nardo, Lorenzo; Virayavanich, W.; Lynch, J. A.; Nevitt, M. C.; McCulloch, C. E.; Majumdar, S.; Link, T. M.

In: Osteoarthritis and Cartilage, Vol. 20, No. 7, 01.07.2012, p. 727-735.

Research output: Contribution to journalArticle

Joseph, G. B. ; Baum, T. ; Alizai, H. ; Carballido-Gamio, J. ; Nardo, Lorenzo ; Virayavanich, W. ; Lynch, J. A. ; Nevitt, M. C. ; McCulloch, C. E. ; Majumdar, S. ; Link, T. M. / Baseline mean and heterogeneity of MR cartilage T 2 are associated with morphologic degeneration of cartilage, meniscus, and bone marrow over 3years - data from the Osteoarthritis Initiative. In: Osteoarthritis and Cartilage. 2012 ; Vol. 20, No. 7. pp. 727-735.
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AU - Baum, T.

AU - Alizai, H.

AU - Carballido-Gamio, J.

AU - Nardo, Lorenzo

AU - Virayavanich, W.

AU - Lynch, J. A.

AU - Nevitt, M. C.

AU - McCulloch, C. E.

AU - Majumdar, S.

AU - Link, T. M.

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AB - Objective: The purpose of this study is to determine whether the mean and heterogeneity of magnetic resonance (MR) knee cartilage T 2 relaxation time measurements at baseline are associated with morphologic degeneration of cartilage, meniscus, and bone marrow tissues over 3years in subjects with risk factors for osteoarthritis (OA). Design: Subjects with risk factors for OA (n=289) with an age range of 45-55years were selected from the Osteoarthritis Initiative (OAI) database. 3.0 Tesla MR images were analyzed using morphological gradings of cartilage, bone marrow and menisci whole-organ magnetic resonance imaging scores (WORMS scoring). A T 2 mapping sequence was used to assess the mean and heterogeneity of cartilage T 2 (gray level co-occurrence matrix texture analysis). Regression models were used to assess the relationship between baseline T 2 parameters and changes in morphologic knee WORMS scores over 3years. Results: The prevalence of knee abnormalities in the cartilage (P<0.0005), meniscus (P<0.00001), and bone marrow significantly (P<0.00001) increased from baseline to 3years in all compartments combined. The baseline mean and heterogeneity of cartilage T 2 were significantly (P<0.05) associated with morphologic joint degeneration in the cartilage, meniscus and bone marrow over 3years. Conclusions: The prevalence of knee abnormalities significantly increased over 3years; increased cartilage T 2 at baseline predicted longitudinal morphologic degeneration in the cartilage, meniscus, and bone marrow over 3years in subjects with risk factors for OA.

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