Abstract
Objective: The purpose of this study is to determine whether the mean and heterogeneity of magnetic resonance (MR) knee cartilage T 2 relaxation time measurements at baseline are associated with morphologic degeneration of cartilage, meniscus, and bone marrow tissues over 3years in subjects with risk factors for osteoarthritis (OA). Design: Subjects with risk factors for OA (n=289) with an age range of 45-55years were selected from the Osteoarthritis Initiative (OAI) database. 3.0 Tesla MR images were analyzed using morphological gradings of cartilage, bone marrow and menisci whole-organ magnetic resonance imaging scores (WORMS scoring). A T 2 mapping sequence was used to assess the mean and heterogeneity of cartilage T 2 (gray level co-occurrence matrix texture analysis). Regression models were used to assess the relationship between baseline T 2 parameters and changes in morphologic knee WORMS scores over 3years. Results: The prevalence of knee abnormalities in the cartilage (P<0.0005), meniscus (P<0.00001), and bone marrow significantly (P<0.00001) increased from baseline to 3years in all compartments combined. The baseline mean and heterogeneity of cartilage T 2 were significantly (P<0.05) associated with morphologic joint degeneration in the cartilage, meniscus and bone marrow over 3years. Conclusions: The prevalence of knee abnormalities significantly increased over 3years; increased cartilage T 2 at baseline predicted longitudinal morphologic degeneration in the cartilage, meniscus, and bone marrow over 3years in subjects with risk factors for OA.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 727-735 |
| Number of pages | 9 |
| Journal | Osteoarthritis and Cartilage |
| Volume | 20 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1 2012 |
| Externally published | Yes |
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Keywords
- Cartilage
- Magnetic Resonance Imaging
- Osteoarthritis
- Osteoarthritis Initiative
- T mapping
ASJC Scopus subject areas
- Biomedical Engineering
- Orthopedics and Sports Medicine
- Rheumatology
Cite this
Baseline mean and heterogeneity of MR cartilage T 2 are associated with morphologic degeneration of cartilage, meniscus, and bone marrow over 3years - data from the Osteoarthritis Initiative. / Joseph, G. B.; Baum, T.; Alizai, H.; Carballido-Gamio, J.; Nardo, Lorenzo; Virayavanich, W.; Lynch, J. A.; Nevitt, M. C.; McCulloch, C. E.; Majumdar, S.; Link, T. M.
In: Osteoarthritis and Cartilage, Vol. 20, No. 7, 01.07.2012, p. 727-735.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Baseline mean and heterogeneity of MR cartilage T 2 are associated with morphologic degeneration of cartilage, meniscus, and bone marrow over 3years - data from the Osteoarthritis Initiative
AU - Joseph, G. B.
AU - Baum, T.
AU - Alizai, H.
AU - Carballido-Gamio, J.
AU - Nardo, Lorenzo
AU - Virayavanich, W.
AU - Lynch, J. A.
AU - Nevitt, M. C.
AU - McCulloch, C. E.
AU - Majumdar, S.
AU - Link, T. M.
PY - 2012/7/1
Y1 - 2012/7/1
N2 - Objective: The purpose of this study is to determine whether the mean and heterogeneity of magnetic resonance (MR) knee cartilage T 2 relaxation time measurements at baseline are associated with morphologic degeneration of cartilage, meniscus, and bone marrow tissues over 3years in subjects with risk factors for osteoarthritis (OA). Design: Subjects with risk factors for OA (n=289) with an age range of 45-55years were selected from the Osteoarthritis Initiative (OAI) database. 3.0 Tesla MR images were analyzed using morphological gradings of cartilage, bone marrow and menisci whole-organ magnetic resonance imaging scores (WORMS scoring). A T 2 mapping sequence was used to assess the mean and heterogeneity of cartilage T 2 (gray level co-occurrence matrix texture analysis). Regression models were used to assess the relationship between baseline T 2 parameters and changes in morphologic knee WORMS scores over 3years. Results: The prevalence of knee abnormalities in the cartilage (P<0.0005), meniscus (P<0.00001), and bone marrow significantly (P<0.00001) increased from baseline to 3years in all compartments combined. The baseline mean and heterogeneity of cartilage T 2 were significantly (P<0.05) associated with morphologic joint degeneration in the cartilage, meniscus and bone marrow over 3years. Conclusions: The prevalence of knee abnormalities significantly increased over 3years; increased cartilage T 2 at baseline predicted longitudinal morphologic degeneration in the cartilage, meniscus, and bone marrow over 3years in subjects with risk factors for OA.
AB - Objective: The purpose of this study is to determine whether the mean and heterogeneity of magnetic resonance (MR) knee cartilage T 2 relaxation time measurements at baseline are associated with morphologic degeneration of cartilage, meniscus, and bone marrow tissues over 3years in subjects with risk factors for osteoarthritis (OA). Design: Subjects with risk factors for OA (n=289) with an age range of 45-55years were selected from the Osteoarthritis Initiative (OAI) database. 3.0 Tesla MR images were analyzed using morphological gradings of cartilage, bone marrow and menisci whole-organ magnetic resonance imaging scores (WORMS scoring). A T 2 mapping sequence was used to assess the mean and heterogeneity of cartilage T 2 (gray level co-occurrence matrix texture analysis). Regression models were used to assess the relationship between baseline T 2 parameters and changes in morphologic knee WORMS scores over 3years. Results: The prevalence of knee abnormalities in the cartilage (P<0.0005), meniscus (P<0.00001), and bone marrow significantly (P<0.00001) increased from baseline to 3years in all compartments combined. The baseline mean and heterogeneity of cartilage T 2 were significantly (P<0.05) associated with morphologic joint degeneration in the cartilage, meniscus and bone marrow over 3years. Conclusions: The prevalence of knee abnormalities significantly increased over 3years; increased cartilage T 2 at baseline predicted longitudinal morphologic degeneration in the cartilage, meniscus, and bone marrow over 3years in subjects with risk factors for OA.
KW - Cartilage
KW - Magnetic Resonance Imaging
KW - Osteoarthritis
KW - Osteoarthritis Initiative
KW - T mapping
UR - http://www.scopus.com/inward/record.url?scp=84862125837&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862125837&partnerID=8YFLogxK
U2 - 10.1016/j.joca.2012.04.003
DO - 10.1016/j.joca.2012.04.003
M3 - Article
C2 - 22503812
AN - SCOPUS:84862125837
VL - 20
SP - 727
EP - 735
JO - Osteoarthritis and Cartilage
JF - Osteoarthritis and Cartilage
SN - 1063-4584
IS - 7
ER -