Baseline exploratory activity predicts anxiolytic responsiveness to diazepam in five mouse strains

Jacqueline Crawley; L. G. Davis

doi:10.1016/0361-9230(82)90087-9

Baseline exploratory activity predicts anxiolytic responsiveness to diazepam in five mouse strains

Jacqueline Crawley, L. G. Davis

Research output: Contribution to journal › Article › peer-review

164 Scopus citations

Abstract

CRAWLEY, J. N. AND L. G. DAVIS. Baseline exploratory activity predicts anxiolytic responsiveness to diazepam in five mouse strains. BRAIN RES. BULL. 8(6) 609-612, 1982-Inbred mouse strains showing variability in spontaneous exploratory behaviors displayed differential responsiveness to diazepam in an anxiety-related exploration model. C57B1/6J, BALB/cJ, Swiss Webster/NIH, Swiss Webster/Harlan Sprague-Dawley, and CF-1 mice demonstrated a significant correlation between baseline exploratory activity and maximal percentage increase in exploratory behavior induced by diazepam. No correlation was seen between those behavioral responses and the characteristics of brain benzodiazepine binding sites in the different strains. Anti-anxiety responsiveness appears to be a function of some genetically-determined substrate for spontaneous exploratory behaviors which may have multiple neurochemical substrates.

Original language	English (US)
Pages (from-to)	609-612
Number of pages	4
Journal	Brain Research Bulletin
Volume	8
Issue number	6
DOIs	https://doi.org/10.1016/0361-9230(82)90087-9
State	Published - 1982
Externally published	Yes

Keywords

Benzodiazepine receptor
Benzodiazepines
Exploratory behavior
Genetic strains-mice

ASJC Scopus subject areas

Neuroscience(all)

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title = "Baseline exploratory activity predicts anxiolytic responsiveness to diazepam in five mouse strains",

abstract = "CRAWLEY, J. N. AND L. G. DAVIS. Baseline exploratory activity predicts anxiolytic responsiveness to diazepam in five mouse strains. BRAIN RES. BULL. 8(6) 609-612, 1982-Inbred mouse strains showing variability in spontaneous exploratory behaviors displayed differential responsiveness to diazepam in an anxiety-related exploration model. C57B1/6J, BALB/cJ, Swiss Webster/NIH, Swiss Webster/Harlan Sprague-Dawley, and CF-1 mice demonstrated a significant correlation between baseline exploratory activity and maximal percentage increase in exploratory behavior induced by diazepam. No correlation was seen between those behavioral responses and the characteristics of brain benzodiazepine binding sites in the different strains. Anti-anxiety responsiveness appears to be a function of some genetically-determined substrate for spontaneous exploratory behaviors which may have multiple neurochemical substrates.",

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AU - Davis, L. G.

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AB - CRAWLEY, J. N. AND L. G. DAVIS. Baseline exploratory activity predicts anxiolytic responsiveness to diazepam in five mouse strains. BRAIN RES. BULL. 8(6) 609-612, 1982-Inbred mouse strains showing variability in spontaneous exploratory behaviors displayed differential responsiveness to diazepam in an anxiety-related exploration model. C57B1/6J, BALB/cJ, Swiss Webster/NIH, Swiss Webster/Harlan Sprague-Dawley, and CF-1 mice demonstrated a significant correlation between baseline exploratory activity and maximal percentage increase in exploratory behavior induced by diazepam. No correlation was seen between those behavioral responses and the characteristics of brain benzodiazepine binding sites in the different strains. Anti-anxiety responsiveness appears to be a function of some genetically-determined substrate for spontaneous exploratory behaviors which may have multiple neurochemical substrates.

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KW - Genetic strains-mice

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Baseline exploratory activity predicts anxiolytic responsiveness to diazepam in five mouse strains

Abstract

Keywords

ASJC Scopus subject areas

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