TY - JOUR
T1 - Baseline exploratory activity predicts anxiolytic responsiveness to diazepam in five mouse strains
AU - Crawley, Jacqueline
AU - Davis, L. G.
PY - 1982
Y1 - 1982
N2 - CRAWLEY, J. N. AND L. G. DAVIS. Baseline exploratory activity predicts anxiolytic responsiveness to diazepam in five mouse strains. BRAIN RES. BULL. 8(6) 609-612, 1982-Inbred mouse strains showing variability in spontaneous exploratory behaviors displayed differential responsiveness to diazepam in an anxiety-related exploration model. C57B1/6J, BALB/cJ, Swiss Webster/NIH, Swiss Webster/Harlan Sprague-Dawley, and CF-1 mice demonstrated a significant correlation between baseline exploratory activity and maximal percentage increase in exploratory behavior induced by diazepam. No correlation was seen between those behavioral responses and the characteristics of brain benzodiazepine binding sites in the different strains. Anti-anxiety responsiveness appears to be a function of some genetically-determined substrate for spontaneous exploratory behaviors which may have multiple neurochemical substrates.
AB - CRAWLEY, J. N. AND L. G. DAVIS. Baseline exploratory activity predicts anxiolytic responsiveness to diazepam in five mouse strains. BRAIN RES. BULL. 8(6) 609-612, 1982-Inbred mouse strains showing variability in spontaneous exploratory behaviors displayed differential responsiveness to diazepam in an anxiety-related exploration model. C57B1/6J, BALB/cJ, Swiss Webster/NIH, Swiss Webster/Harlan Sprague-Dawley, and CF-1 mice demonstrated a significant correlation between baseline exploratory activity and maximal percentage increase in exploratory behavior induced by diazepam. No correlation was seen between those behavioral responses and the characteristics of brain benzodiazepine binding sites in the different strains. Anti-anxiety responsiveness appears to be a function of some genetically-determined substrate for spontaneous exploratory behaviors which may have multiple neurochemical substrates.
KW - Benzodiazepine receptor
KW - Benzodiazepines
KW - Exploratory behavior
KW - Genetic strains-mice
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U2 - 10.1016/0361-9230(82)90087-9
DO - 10.1016/0361-9230(82)90087-9
M3 - Article
C2 - 6890398
AN - SCOPUS:0020380029
VL - 8
SP - 609
EP - 612
JO - Journal of Electrophysiological Techniques
JF - Journal of Electrophysiological Techniques
SN - 0361-9230
IS - 6
ER -