Baseline exploratory activity predicts anxiolytic responsiveness to diazepam in five mouse strains

Jacqueline Crawley, L. G. Davis

Research output: Contribution to journalArticle

163 Scopus citations

Abstract

CRAWLEY, J. N. AND L. G. DAVIS. Baseline exploratory activity predicts anxiolytic responsiveness to diazepam in five mouse strains. BRAIN RES. BULL. 8(6) 609-612, 1982-Inbred mouse strains showing variability in spontaneous exploratory behaviors displayed differential responsiveness to diazepam in an anxiety-related exploration model. C57B1/6J, BALB/cJ, Swiss Webster/NIH, Swiss Webster/Harlan Sprague-Dawley, and CF-1 mice demonstrated a significant correlation between baseline exploratory activity and maximal percentage increase in exploratory behavior induced by diazepam. No correlation was seen between those behavioral responses and the characteristics of brain benzodiazepine binding sites in the different strains. Anti-anxiety responsiveness appears to be a function of some genetically-determined substrate for spontaneous exploratory behaviors which may have multiple neurochemical substrates.

Original languageEnglish (US)
Pages (from-to)609-612
Number of pages4
JournalBrain Research Bulletin
Volume8
Issue number6
DOIs
StatePublished - 1982
Externally publishedYes

Keywords

  • Benzodiazepine receptor
  • Benzodiazepines
  • Exploratory behavior
  • Genetic strains-mice

ASJC Scopus subject areas

  • Neuroscience(all)

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