Baseline exploratory activity predicts anxiolytic responsiveness to diazepam in five mouse strains

Jacqueline Crawley; L. G. Davis

doi:10.1016/0361-9230(82)90087-9

Baseline exploratory activity predicts anxiolytic responsiveness to diazepam in five mouse strains

Jacqueline Crawley, L. G. Davis

Research output: Contribution to journal › Article › peer-review

163 Scopus citations

Abstract

CRAWLEY, J. N. AND L. G. DAVIS. Baseline exploratory activity predicts anxiolytic responsiveness to diazepam in five mouse strains. BRAIN RES. BULL. 8(6) 609-612, 1982-Inbred mouse strains showing variability in spontaneous exploratory behaviors displayed differential responsiveness to diazepam in an anxiety-related exploration model. C57B1/6J, BALB/cJ, Swiss Webster/NIH, Swiss Webster/Harlan Sprague-Dawley, and CF-1 mice demonstrated a significant correlation between baseline exploratory activity and maximal percentage increase in exploratory behavior induced by diazepam. No correlation was seen between those behavioral responses and the characteristics of brain benzodiazepine binding sites in the different strains. Anti-anxiety responsiveness appears to be a function of some genetically-determined substrate for spontaneous exploratory behaviors which may have multiple neurochemical substrates.

Original language	English (US)
Pages (from-to)	609-612
Number of pages	4
Journal	Brain Research Bulletin
Volume	8
Issue number	6
DOIs	https://doi.org/10.1016/0361-9230(82)90087-9
State	Published - 1982
Externally published	Yes

Keywords

Benzodiazepine receptor
Benzodiazepines
Exploratory behavior
Genetic strains-mice

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1016/0361-9230(82)90087-9

Fingerprint Dive into the research topics of 'Baseline exploratory activity predicts anxiolytic responsiveness to diazepam in five mouse strains'. Together they form a unique fingerprint.

Cite this

@article{cf648d872b664abebababc08f3eab62c,

title = "Baseline exploratory activity predicts anxiolytic responsiveness to diazepam in five mouse strains",

abstract = "CRAWLEY, J. N. AND L. G. DAVIS. Baseline exploratory activity predicts anxiolytic responsiveness to diazepam in five mouse strains. BRAIN RES. BULL. 8(6) 609-612, 1982-Inbred mouse strains showing variability in spontaneous exploratory behaviors displayed differential responsiveness to diazepam in an anxiety-related exploration model. C57B1/6J, BALB/cJ, Swiss Webster/NIH, Swiss Webster/Harlan Sprague-Dawley, and CF-1 mice demonstrated a significant correlation between baseline exploratory activity and maximal percentage increase in exploratory behavior induced by diazepam. No correlation was seen between those behavioral responses and the characteristics of brain benzodiazepine binding sites in the different strains. Anti-anxiety responsiveness appears to be a function of some genetically-determined substrate for spontaneous exploratory behaviors which may have multiple neurochemical substrates.",

keywords = "Benzodiazepine receptor, Benzodiazepines, Exploratory behavior, Genetic strains-mice",

author = "Jacqueline Crawley and Davis, {L. G.}",

year = "1982",

doi = "10.1016/0361-9230(82)90087-9",

language = "English (US)",

volume = "8",

pages = "609--612",

journal = "Brain Research Bulletin",

issn = "0361-9230",

publisher = "Elsevier Inc.",

number = "6",

}

TY - JOUR

T1 - Baseline exploratory activity predicts anxiolytic responsiveness to diazepam in five mouse strains

AU - Crawley, Jacqueline

AU - Davis, L. G.

PY - 1982

Y1 - 1982

N2 - CRAWLEY, J. N. AND L. G. DAVIS. Baseline exploratory activity predicts anxiolytic responsiveness to diazepam in five mouse strains. BRAIN RES. BULL. 8(6) 609-612, 1982-Inbred mouse strains showing variability in spontaneous exploratory behaviors displayed differential responsiveness to diazepam in an anxiety-related exploration model. C57B1/6J, BALB/cJ, Swiss Webster/NIH, Swiss Webster/Harlan Sprague-Dawley, and CF-1 mice demonstrated a significant correlation between baseline exploratory activity and maximal percentage increase in exploratory behavior induced by diazepam. No correlation was seen between those behavioral responses and the characteristics of brain benzodiazepine binding sites in the different strains. Anti-anxiety responsiveness appears to be a function of some genetically-determined substrate for spontaneous exploratory behaviors which may have multiple neurochemical substrates.

AB - CRAWLEY, J. N. AND L. G. DAVIS. Baseline exploratory activity predicts anxiolytic responsiveness to diazepam in five mouse strains. BRAIN RES. BULL. 8(6) 609-612, 1982-Inbred mouse strains showing variability in spontaneous exploratory behaviors displayed differential responsiveness to diazepam in an anxiety-related exploration model. C57B1/6J, BALB/cJ, Swiss Webster/NIH, Swiss Webster/Harlan Sprague-Dawley, and CF-1 mice demonstrated a significant correlation between baseline exploratory activity and maximal percentage increase in exploratory behavior induced by diazepam. No correlation was seen between those behavioral responses and the characteristics of brain benzodiazepine binding sites in the different strains. Anti-anxiety responsiveness appears to be a function of some genetically-determined substrate for spontaneous exploratory behaviors which may have multiple neurochemical substrates.

KW - Benzodiazepine receptor

KW - Benzodiazepines

KW - Exploratory behavior

KW - Genetic strains-mice

UR - http://www.scopus.com/inward/record.url?scp=0020380029&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020380029&partnerID=8YFLogxK

U2 - 10.1016/0361-9230(82)90087-9

DO - 10.1016/0361-9230(82)90087-9

M3 - Article

C2 - 6890398

AN - SCOPUS:0020380029

VL - 8

SP - 609

EP - 612

JO - Brain Research Bulletin

JF - Brain Research Bulletin

SN - 0361-9230

IS - 6

ER -