Basal forebrain carbachol injection reduces cortical acetylcholine turnover and disrupts memory

Susan E. Robinson, Kristi L. Hambrecht, Bruce G Lyeth

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Injection of the cholinergic agonist carbachol into the region of cholinergic cell bodies in the basal forebrain decreases the turnover rate of acetylcholine in the cortex of the rat, as measured by a mass fragmentographic technique. Moreover, this treatment has been found to increase the number of working memory errors committed as measured in the 8-arm radial maze. These results suggest an inhibitory cholinergic mechanism on the cell bodies of basal forebrain neurons which may be important in memory and the treatment of Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)160-164
Number of pages5
JournalBrain Research
Volume445
Issue number1
DOIs
StatePublished - Mar 29 1988
Externally publishedYes

Keywords

  • Acetylcholine turnover
  • Basal forebrain
  • Carbachol
  • Cortex
  • Working memory

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Basal forebrain carbachol injection reduces cortical acetylcholine turnover and disrupts memory'. Together they form a unique fingerprint.

  • Cite this