Basal Cell Carcinoma

Research output: Chapter in Book/Report/Conference proceedingChapter


Basal cell carcinoma (BCC) is a type of skin cancer that generally occurs in areas of chronically sun-damaged skin. BCCs are the most common form of human malignancy. Although they rarely metastasize, BCCs can be locally invasive and cause extensive destruction around the primary tumor site. Several genetic mutations involving the sonic hedgehog signaling pathway have been characterized in basal cell nevus syndrome, an inherited disease characterized by increased susceptibility to BCC development. Similar mutations have also been observed in sporadic cases of BCC.

Original languageEnglish (US)
Title of host publicationBrenner's Encyclopedia of Genetics
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Number of pages1
ISBN (Electronic)9780080961569
ISBN (Print)9780123749840
StatePublished - Feb 27 2013
Externally publishedYes


  • Basal cell carcinoma
  • Gorlin syndrome
  • Patched
  • Skin cancer
  • Sonic hedgehog

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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