Barrett's esophagus in patients with symptomatic reflux esophagitis

Nirmal S Mann, M. F. Tsai, P. K. Nair

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

We evaluated the frequency with which Barrett's esophagus (BE) occurs in patients with symptomatic reflux esophagitis, and compared the clinical endoscopic and manometric features of patients with Barrett's esophagus with those of patients who had non-Barrett's esophagitis (NBE). The effect of 6 months' medical treatment on BE patients was reevaluated by repeating manometry, endoscopy, and biopsy. Esophageal manometry was performed by perfusion technique and endoscopic biopsies were obtained. There were 180 patients; 20 (11%) were found to have BE. The vast majority of BE patients were caucasians. BE patients had symptoms of gastroesophageal reflux for a longer time than did NBE patients. Mean lower esophageal sphincter pressure in BE patients was lower than that in NBE patients. On medical treatment, the severity of esophagitis as judged by endoscopic criteria in BE patients was reduced, but there was no increase in lower esophageal sphincter pressure and no regression of the columnar epithelium.

Original languageEnglish (US)
Pages (from-to)1494-1496
Number of pages3
JournalAmerican Journal of Gastroenterology
Volume84
Issue number12
StatePublished - 1989
Externally publishedYes

Fingerprint

Peptic Esophagitis
Barrett Esophagus
Esophagitis
Lower Esophageal Sphincter
Manometry
Biopsy
Pressure
Gastroesophageal Reflux
Endoscopy
Epithelium
Perfusion

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Barrett's esophagus in patients with symptomatic reflux esophagitis. / Mann, Nirmal S; Tsai, M. F.; Nair, P. K.

In: American Journal of Gastroenterology, Vol. 84, No. 12, 1989, p. 1494-1496.

Research output: Contribution to journalArticle

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