Baroreflex sensitivity during the gravitational stimulus: Physiology and pathophysiology

Raffaello Furlan, Franca Dipaola, Veronica Pacetti, Carlo Selmi, Francesca Meda, Ilaria Bianchi, Franca Barbic

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Baroreceptor mechanisms play a crucial role in healthy humans during a gravitational stimulus to maintain blood pressure and cerebral perfusion by providing proper orthostatic tolerance. In addition, they concur to synchronize central neural discharge activity and hemodynamic spontaneous fluctuations leading to an optimal interaction between the cardiovascular neural regulatory activity and the heart and vessel response. In pathophysiological conditions as encountered before tilt induced neurally-mediated syncope, the gain of baroreflex control of heart rate and muscle sympathetic nerve activity (MSNA) is remarkably impaired, revealing a diminished capability to adapt in response to similar changes of blood pressure compared to healthy subjects. The loss of an organized post-ganglionic sympathetic discharge activity to the vessel leads to orthostatic intolerance in subjects with baroreceptor failure.

Original languageEnglish (US)
Title of host publication1st International Workshop on Innovative Simulation for Health Care, IWISH 2012, Held at the International Multidisciplinary Modeling and Simulation Multiconference, I3M 2012
PublisherCaltek s.r.l.
Pages172-174
Number of pages3
StatePublished - 2012
Externally publishedYes
Event1st International Workshop on Innovative Simulation for Health Care, IWISH 2012, Held at the International Multidisciplinary Modeling and Simulation Multiconference, I3M 2012 - Vienna, Austria
Duration: Sep 19 2012Sep 21 2012

Other

Other1st International Workshop on Innovative Simulation for Health Care, IWISH 2012, Held at the International Multidisciplinary Modeling and Simulation Multiconference, I3M 2012
CountryAustria
CityVienna
Period9/19/129/21/12

Keywords

  • Baroreflex sensitivity
  • Cardiovascular sympathetic activity
  • Gravitational stimulus
  • Muscle sympathetic nerve activity

ASJC Scopus subject areas

  • Modeling and Simulation
  • Health Informatics

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