Barbiturate serum levels and protection against kindled amygdaloid seizures in the rat

Timothy E Albertson, S. L. Peterson, L. G. Stark, R. C. Baselt

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The barbiturates have been reported to be very effective against kindled amygdaloid seizures in the rat. In this study, the anticonvulsant effectiveness of pentobarbital, phenobarbital and primidone was studied in a systematic, multiple-dose evaluation. A correlation at 30 min between increased anticonvulsant protection and increased serum levels of pentobarbital and phenobarbital was seen. A possible correlation at 30 min, 2 hr and 48 hr between summed serum levels of the metabolites phenylethylmalonamide and phenobarbital was seen with the primidone treated animals. Serum primidone levels appeared to contribute little to the delayed protection against kindled amygdaloid seizures seen with primidone.

Original languageEnglish (US)
Pages (from-to)1141-1144
Number of pages4
JournalNeuropharmacology
Volume19
Issue number11
DOIs
StatePublished - 1980

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

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