The barbiturates have been reported to be very effective against kindled amygdaloid seizures in the rat. In this study, the anticonvulsant effectiveness of pentobarbital, phenobarbital and primidone was studied in a systematic, multiple-dose evaluation. A correlation at 30 min between increased anticonvulsant protection and increased serum levels of pentobarbital and phenobarbital was seen. A possible correlation at 30 min, 2 hr and 48 hr between summed serum levels of the metabolites phenylethylmalonamide and phenobarbital was seen with the primidone treated animals. Serum primidone levels appeared to contribute little to the delayed protection against kindled amygdaloid seizures seen with primidone.
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Drug Discovery