TY - JOUR
T1 - Banding resolution of human chromosomes
T2 - A method of accuracy and simplicity
AU - Welborn, Jeanna L
AU - Welborn, R.
PY - 1993
Y1 - 1993
N2 - Methods of estimating chromosome band resolution have been published but their accuracy has not been established. Banding resolution was determined by 4 methods which included a computerized linear correlation, the sum of bands on chromosomes 1 and 2, interpolation of the number of bands on chromosome 10, and interpolation of the number of bands on chromosomes 1p, 10, 11p, 12q, and X. The sum of bands on chromosomes 1 and 2 multiplied by 6 is the most accurate and simple. The use of a simple and reliable method is important for cytogenetic laboratories to document quality assurance of routine chromosome analyses, to enhance the exchange of information between laboratories, and to establish criteria for appropriate band resolution for specific types of specimens.
AB - Methods of estimating chromosome band resolution have been published but their accuracy has not been established. Banding resolution was determined by 4 methods which included a computerized linear correlation, the sum of bands on chromosomes 1 and 2, interpolation of the number of bands on chromosome 10, and interpolation of the number of bands on chromosomes 1p, 10, 11p, 12q, and X. The sum of bands on chromosomes 1 and 2 multiplied by 6 is the most accurate and simple. The use of a simple and reliable method is important for cytogenetic laboratories to document quality assurance of routine chromosome analyses, to enhance the exchange of information between laboratories, and to establish criteria for appropriate band resolution for specific types of specimens.
KW - band level
KW - human chromosomes
KW - methods of estimation
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U2 - 10.1002/ajmg.1320470810
DO - 10.1002/ajmg.1320470810
M3 - Article
C2 - 8291552
AN - SCOPUS:0027380057
VL - 47
SP - 1180
EP - 1183
JO - American Journal of Medical Genetics
JF - American Journal of Medical Genetics
SN - 1552-4825
IS - 8
ER -