Bacterial vaginosis is a strong predictor of Neisseria gonorrhoeae and Chlamydia trachomatis infection

Harold C. Wiesenfeld, Sharon L. Hillier, Marijane A. Krohn, Daniel V. Landers, Richard L Sweet

Research output: Contribution to journalArticle

304 Citations (Scopus)

Abstract

To evaluate whether bacterial vaginosis predicts the acquisition of sexually transmitted diseases (STDs), we studied 255 nonpregnant female subjects aged 15-30 who reported recent sexual contact with a male partner in whom either gonococcal or chlamydial urethritis or nongonococcal urethritis was diagnosed. Compared to subjects with normal vaginal flora, subjects with bacterial vaginosis were more likely to test positive for Neisseria gonorrhoeae (odds ratio [OR], 4.1; 95% confidence interval [CI], 1.7-9.7) and Chlamydia trachomatis (OR, 3.4; 95% CI, 1.5-7.8). Subjects colonized vaginally by hydrogen peroxide-producing lactobacilli were less likely to receive a diagnosis of chlamydial infection or gonorrhea than subjects without such lactobacilli. Bacterial vaginosis was a strong predictor of gonorrhea and chlamydial infection among subjects who reported recent exposure to a male partner with urethritis. These data support the importance of vaginal flora in the defense against STD acquisition.

Original languageEnglish (US)
Pages (from-to)663-668
Number of pages6
JournalClinical Infectious Diseases
Volume36
Issue number5
DOIs
StatePublished - Mar 1 2003
Externally publishedYes

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Bacterial Vaginosis
Urethritis
Chlamydia Infections
Neisseria gonorrhoeae
Chlamydia trachomatis
Gonorrhea
Lactobacillus
Sexually Transmitted Diseases
Odds Ratio
Confidence Intervals
Infection
Hydrogen Peroxide

ASJC Scopus subject areas

  • Immunology

Cite this

Bacterial vaginosis is a strong predictor of Neisseria gonorrhoeae and Chlamydia trachomatis infection. / Wiesenfeld, Harold C.; Hillier, Sharon L.; Krohn, Marijane A.; Landers, Daniel V.; Sweet, Richard L.

In: Clinical Infectious Diseases, Vol. 36, No. 5, 01.03.2003, p. 663-668.

Research output: Contribution to journalArticle

Wiesenfeld, Harold C. ; Hillier, Sharon L. ; Krohn, Marijane A. ; Landers, Daniel V. ; Sweet, Richard L. / Bacterial vaginosis is a strong predictor of Neisseria gonorrhoeae and Chlamydia trachomatis infection. In: Clinical Infectious Diseases. 2003 ; Vol. 36, No. 5. pp. 663-668.
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