Bacterial Urinary Tract Infections Associated with Transitional Cell Carcinoma in Dogs

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Abstract

Background: Urinary tract infections (UTI) are believed to be common in dogs with transitional cell carcinoma (TCC), but incidence and contributing factors have not been reported. Objectives: To determine the frequency and bacterial agents associated with UTI in dogs with TCC and define contributing factors. Animals: Eighty-five dogs with a history of urogenital TCC undergoing treatment with chemotherapy that had at least 1 urine culture performed. Methods: Medical records and culture results were retrospectively reviewed and ultrasound images were reviewed when available. Clinical factors were evaluated statistically for association with positive culture. Results: Fifty-five percent (47/85) of dogs had at least 1 positive culture during the course of treatment. Female dogs (80%, 40/50) were more likely than male dogs (29%, 10/35) to have at least 1 positive culture. Ultrasound examination determined that female dogs were more likely to have urethral (74%, 31/42) or trigonal tumor involvement (71%, 30/42) compared to male dogs (32%, 9/28 and 43%, 12/28, respectively). The most commonly isolated organisms were Staphylococcus spp. (23.9%, 29/121) and Escherichia coli (19.8%, 24/121). Dogs with urethral involvement of TCC were significantly more likely to have at least 1 positive culture than dogs without urethral involvement (75%, 30/40 versus 30%, 9/30). Conclusions: Urinary tract infection is common in dogs with TCC highlighting the importance of regular monitoring for bacterial cystitis in dogs with TCC. In addition, clinical factors such as tumor location and sex may be predictive of positive culture and can help clinicians assess the risk of UTI.

Original languageEnglish (US)
Pages (from-to)828-833
Number of pages6
JournalJournal of Veterinary Internal Medicine
Volume29
Issue number3
DOIs
StatePublished - May 1 2015

Fingerprint

urinary tract diseases
Transitional Cell Carcinoma
Urinary Tract Infections
carcinoma
Dogs
dogs
cells
cystitis
neoplasms
Cystitis
Staphylococcus
drug therapy
Medical Records
Neoplasms

Keywords

  • Canine
  • Neoplasia
  • Urethral

ASJC Scopus subject areas

  • veterinary(all)

Cite this

@article{2b65271a74e64f60bad701db0e7a23da,
title = "Bacterial Urinary Tract Infections Associated with Transitional Cell Carcinoma in Dogs",
abstract = "Background: Urinary tract infections (UTI) are believed to be common in dogs with transitional cell carcinoma (TCC), but incidence and contributing factors have not been reported. Objectives: To determine the frequency and bacterial agents associated with UTI in dogs with TCC and define contributing factors. Animals: Eighty-five dogs with a history of urogenital TCC undergoing treatment with chemotherapy that had at least 1 urine culture performed. Methods: Medical records and culture results were retrospectively reviewed and ultrasound images were reviewed when available. Clinical factors were evaluated statistically for association with positive culture. Results: Fifty-five percent (47/85) of dogs had at least 1 positive culture during the course of treatment. Female dogs (80{\%}, 40/50) were more likely than male dogs (29{\%}, 10/35) to have at least 1 positive culture. Ultrasound examination determined that female dogs were more likely to have urethral (74{\%}, 31/42) or trigonal tumor involvement (71{\%}, 30/42) compared to male dogs (32{\%}, 9/28 and 43{\%}, 12/28, respectively). The most commonly isolated organisms were Staphylococcus spp. (23.9{\%}, 29/121) and Escherichia coli (19.8{\%}, 24/121). Dogs with urethral involvement of TCC were significantly more likely to have at least 1 positive culture than dogs without urethral involvement (75{\%}, 30/40 versus 30{\%}, 9/30). Conclusions: Urinary tract infection is common in dogs with TCC highlighting the importance of regular monitoring for bacterial cystitis in dogs with TCC. In addition, clinical factors such as tumor location and sex may be predictive of positive culture and can help clinicians assess the risk of UTI.",
keywords = "Canine, Neoplasia, Urethral",
author = "Budreckis, {D. M.} and Byrne, {Barbara A} and Pollard, {Rachel E} and Rebhun, {Robert B} and Rodriguez, {C. O.} and Skorupski, {Katherine A}",
year = "2015",
month = "5",
day = "1",
doi = "10.1111/jvim.12578",
language = "English (US)",
volume = "29",
pages = "828--833",
journal = "Journal of Veterinary Internal Medicine",
issn = "0891-6640",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Bacterial Urinary Tract Infections Associated with Transitional Cell Carcinoma in Dogs

AU - Budreckis, D. M.

AU - Byrne, Barbara A

AU - Pollard, Rachel E

AU - Rebhun, Robert B

AU - Rodriguez, C. O.

AU - Skorupski, Katherine A

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Background: Urinary tract infections (UTI) are believed to be common in dogs with transitional cell carcinoma (TCC), but incidence and contributing factors have not been reported. Objectives: To determine the frequency and bacterial agents associated with UTI in dogs with TCC and define contributing factors. Animals: Eighty-five dogs with a history of urogenital TCC undergoing treatment with chemotherapy that had at least 1 urine culture performed. Methods: Medical records and culture results were retrospectively reviewed and ultrasound images were reviewed when available. Clinical factors were evaluated statistically for association with positive culture. Results: Fifty-five percent (47/85) of dogs had at least 1 positive culture during the course of treatment. Female dogs (80%, 40/50) were more likely than male dogs (29%, 10/35) to have at least 1 positive culture. Ultrasound examination determined that female dogs were more likely to have urethral (74%, 31/42) or trigonal tumor involvement (71%, 30/42) compared to male dogs (32%, 9/28 and 43%, 12/28, respectively). The most commonly isolated organisms were Staphylococcus spp. (23.9%, 29/121) and Escherichia coli (19.8%, 24/121). Dogs with urethral involvement of TCC were significantly more likely to have at least 1 positive culture than dogs without urethral involvement (75%, 30/40 versus 30%, 9/30). Conclusions: Urinary tract infection is common in dogs with TCC highlighting the importance of regular monitoring for bacterial cystitis in dogs with TCC. In addition, clinical factors such as tumor location and sex may be predictive of positive culture and can help clinicians assess the risk of UTI.

AB - Background: Urinary tract infections (UTI) are believed to be common in dogs with transitional cell carcinoma (TCC), but incidence and contributing factors have not been reported. Objectives: To determine the frequency and bacterial agents associated with UTI in dogs with TCC and define contributing factors. Animals: Eighty-five dogs with a history of urogenital TCC undergoing treatment with chemotherapy that had at least 1 urine culture performed. Methods: Medical records and culture results were retrospectively reviewed and ultrasound images were reviewed when available. Clinical factors were evaluated statistically for association with positive culture. Results: Fifty-five percent (47/85) of dogs had at least 1 positive culture during the course of treatment. Female dogs (80%, 40/50) were more likely than male dogs (29%, 10/35) to have at least 1 positive culture. Ultrasound examination determined that female dogs were more likely to have urethral (74%, 31/42) or trigonal tumor involvement (71%, 30/42) compared to male dogs (32%, 9/28 and 43%, 12/28, respectively). The most commonly isolated organisms were Staphylococcus spp. (23.9%, 29/121) and Escherichia coli (19.8%, 24/121). Dogs with urethral involvement of TCC were significantly more likely to have at least 1 positive culture than dogs without urethral involvement (75%, 30/40 versus 30%, 9/30). Conclusions: Urinary tract infection is common in dogs with TCC highlighting the importance of regular monitoring for bacterial cystitis in dogs with TCC. In addition, clinical factors such as tumor location and sex may be predictive of positive culture and can help clinicians assess the risk of UTI.

KW - Canine

KW - Neoplasia

KW - Urethral

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U2 - 10.1111/jvim.12578

DO - 10.1111/jvim.12578

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C2 - 25940672

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VL - 29

SP - 828

EP - 833

JO - Journal of Veterinary Internal Medicine

JF - Journal of Veterinary Internal Medicine

SN - 0891-6640

IS - 3

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