Bacteria, the endoplasmic reticulum and the unfolded protein response: Friends or foes?

Jean Celli, Renee M Tsolis

Research output: Contribution to journalArticlepeer-review

97 Scopus citations

Abstract

The unfolded protein response (UPR) is a cytoprotective response that is aimed at restoring cellular homeostasis following physiological stress exerted on the endoplasmic reticulum (ER), which also invokes innate immune signalling in response to invading microorganisms. Although it has been known for some time that the UPR is modulated by various viruses, recent evidence indicates that it also has multiple roles during bacterial infections. In this Review, we describe how bacteria interact with the ER, including how bacteria induce the UPR, how subversion of the UPR promotes bacterial proliferation and how the UPR contributes to innate immune responses against invading bacteria.

Original languageEnglish (US)
Pages (from-to)71-82
Number of pages12
JournalNature Reviews Microbiology
Volume13
Issue number2
DOIs
StatePublished - Feb 16 2015

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Medicine(all)

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