Bacteria and human autoimmunity: The case of primary biliary cirrhosis

Carlo Selmi, M. Eric Gershwin

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Purpose of review: Primary biliary cirrhosis is a chronic inflammatory disease of the intrahepatic bile ducts that eventually leads to liver cirrhosis and organ failure, in which several observations suggest an autoimmune origin. Similarly to other autoimmune diseases, microbial mediated molecular mimicry is the most widely studied trigger that may break immunologic tolerance in primary biliary cirrhosis. Recent findings: The hypothesis of a bacterial role in the cause of primary biliary cirrhosis has received recent attention, based on in vitro data and the identification of a unique xenobiotic-metabolizing bacterium that modulates naturally occurring environmental estrogens, namely, Novosphingobium aromaticivorans. Summary: The evidence indicates that bacteria, through different mechanisms, may precipitate autoimmunity in primary biliary cirrhosis and other autoimmune diseases. These data have several implications.

Original languageEnglish (US)
Pages (from-to)406-410
Number of pages5
JournalCurrent Opinion in Rheumatology
Volume16
Issue number4
DOIs
StatePublished - Jul 2004

Fingerprint

Biliary Liver Cirrhosis
Autoimmunity
Bacteria
Autoimmune Diseases
Molecular Mimicry
Intrahepatic Bile Ducts
Xenobiotics
Liver Cirrhosis
Estrogens
Chronic Disease

Keywords

  • Bacteria
  • Molecular mimicry
  • Primary biliary cirrhosis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Bacteria and human autoimmunity : The case of primary biliary cirrhosis. / Selmi, Carlo; Gershwin, M. Eric.

In: Current Opinion in Rheumatology, Vol. 16, No. 4, 07.2004, p. 406-410.

Research output: Contribution to journalArticle

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